| Status | 已發表Published |
| Building potent chimeric antigen receptor T cells with CRISPR genome editing | |
Liu, J. ; Zhou, G.; Zhang, L.; Zhao, Q.
| |
| 2019-03-19 | |
| Source Publication | Frontiers in Immunology
 |
| ISSN | 1664-3224 |
| Pages | 456-456 |
| Abstract | Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of hematological and solid malignancies. However, despite the success of this field, there remain some major challenges, including accelerated T cell exhaustion, potential toxicities, and insertional oncogenesis. To overcome these limitations, recent advances in CRISPR technology have enabled targetable interventions of endogenous genes in human CAR T cells. These CRISPR genome editing approaches have unleashed the therapeutic potential of CAR T cell therapy. Here, we summarize the potential benefits, safety concerns, and difficulties in the generation of gene-edited CAR T cells using CRISPR technology. |
| Keyword | chimeric antigen receptor CRISPR gene editing immunotherapy cancer CAR T |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 45912 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Zhao, Q. |
| Recommended Citation GB/T 7714 | Liu, J.,Zhou, G.,Zhang, L.,et al. Building potent chimeric antigen receptor T cells with CRISPR genome editing[J]. Frontiers in Immunology, 2019, 456-456. |
| APA | Liu, J.., Zhou, G.., Zhang, L.., & Zhao, Q. (2019). Building potent chimeric antigen receptor T cells with CRISPR genome editing. Frontiers in Immunology, 456-456. |
| MLA | Liu, J.,et al."Building potent chimeric antigen receptor T cells with CRISPR genome editing".Frontiers in Immunology (2019):456-456. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment