B7-H3, a checkpoint molecule, as a target for cancer immunotherapy

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	B7-H3, a checkpoint molecule, as a target for cancer immunotherapy
	Yang, S.; Wei, W.; Zhao, Q.
	2020-03-25
Source Publication	International Journal of Biological Sciences
ISSN	1449-2288
Pages	1767-1773
Abstract	B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and prostate cancer. Its expression is highly associated with undesirable treatment outcomes and survival time, due to function of the immune checkpoint molecule. It was classified as either a co-stimulatory molecule for T cell activation or the nonimmunological role of regulating signaling pathways. Although there is still no agreed conclusion on the function of B7-H3, it may be a valuable target for cancer therapy. This review aims to provide a comprehensive, up-to-date summary of the advances in B7-H3 targeting approaches in cancer therapy. Although several challenges remain, B7-H3 offers a new therapeutic target with increased efficacy and less toxicity in future cancer treatment.
Keyword	B7-H3 CD276 antibody cancer immunotherapy immune checkpoint
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	52279
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Wei, W.; Zhao, Q.
Recommended Citation GB/T 7714	Yang, S.,Wei, W.,Zhao, Q.. B7-H3, a checkpoint molecule, as a target for cancer immunotherapy[J]. International Journal of Biological Sciences, 2020, 1767-1773.
APA	Yang, S.., Wei, W.., & Zhao, Q. (2020). B7-H3, a checkpoint molecule, as a target for cancer immunotherapy. International Journal of Biological Sciences, 1767-1773.
MLA	Yang, S.,et al."B7-H3, a checkpoint molecule, as a target for cancer immunotherapy".International Journal of Biological Sciences (2020):1767-1773.

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