NIR-II dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy

UM > Faculty of Health Sciences > DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION

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	NIR-II dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy
	Liu, YB; XU, MZ; Dai, Y.; Zhao, Q.; Zhu, LP; Guan, XW; Li, G.; Yang, SH; Yuan, Z.
	2020-03-30
Source Publication	ACS Applied Polymer Materials
ISSN	2637-6105
Pages	1964-1973
Abstract	In this study, an organic nanodrug delivery platform was constructed as a biocompatible cancer chemotherapeutic system, in which clinically approved sorafenib was loaded in the redox-responsive polymeric micelles, enabling dose-control release of drug to cancer tissues. In addition, visualizing tumor microenvironment changes is also essential for cancer chemotherapy, which can provide a priori and feedback control of drug delivery with reduced side effects. Therefore, second near-infrared window (NIR-II) dual-modal optical coherence tomography (OCT) and photoacoustic imaging were performed for real-time visualization of the tumor microenvironment changes in vivo during chemotherapy. In particular, the tumor angiogenesis, the vascular networks density change, and the quantitative total hemoglobin concentration and oxygen saturation of cancer tissues were carefully characterized for individually optimized cancer chemotherapy. It was discovered that the final tumor growth inhibition by dual-modal imaging-guided dose-control chemotherapy can be up to 94.6% during a 30-day treatment, which is much higher than the efficacy from presently utilized tumor treatment options. Herein, the combination of a redox-responsive theranostic agent and NIR-II dual-modal OCT and photoacoustic imaging paved a novel avenue both for guiding dosage control of antiangiogenic drugs to avoid toxic effects and for monitoring and inspecting tumor microenvironment changes while substantially enhancing tumor penetration and antitumor efficacy.
Keyword	OCT photoacoustic imaging biomedical optics nanomedicine tumor cancer molecular imaging tumor microenvironment polymeric micelles chemotherapy
Language	英語English
The Source to Article	PB_Publication
PUB ID	51580
Document Type	Journal article
Collection	DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Corresponding Author	Yuan, Z.
Recommended Citation GB/T 7714	Liu, YB,XU, MZ,Dai, Y.,et al. NIR-II dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy[J]. ACS Applied Polymer Materials, 2020, 1964-1973.
APA	Liu, YB., XU, MZ., Dai, Y.., Zhao, Q.., Zhu, LP., Guan, XW., Li, G.., Yang, SH., & Yuan, Z. (2020). NIR-II dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy. ACS Applied Polymer Materials, 1964-1973.
MLA	Liu, YB,et al."NIR-II dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy".ACS Applied Polymer Materials (2020):1964-1973.

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