Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment

UM > Faculty of Health Sciences > DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION

Status	已發表Published
	Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment
	Zhang, Z.; Sang, W.; Xie, L.; Li, W.; Li, B.; Li, J.; Tian, H.; Yuan, Z.; Zhao, Q.; Dai, Y.
	2021-01-25
Source Publication	Angewandte Chemie International Edition
ISSN	1433-7851
Pages	1967-1975
Abstract	Engineering multifunctional nanoplatforms with high therapeutic benefits has become a promising strategy for intractable cancer treatment. A novel polyphenol-based nanocomplex was designed to evoke highly efficacious cancer immunosurveillance while localizing therapy on the primary tumor and to minimize systemic side effects. This nanocomplex is prepared via metal-polyphenol coordination by encapsulating a natural polyphenol, gossypol, and a newly synthesized polyphenol derivative, polyethylene glycol-Chlorin e6 (Ce6). The combination of gossypol from cotton and the photosensitizer Ce6 can induce chemotherapeutic/photodynamic immunogenic cancer cell death upon laser irradiation, which is supported by a rich maturation of dendritic cells, concentrated secretion of inflammatory cytokines, and significant inhibition of distant untreated tumors. Finally, an assistance of the programmed-cell-death ligand-1 checkpoint-blockade immunotherapy can enhance the anti-tumor immune stimulation of our nanoplatform to a higher level.
Keyword	PD-L1 checkpoint blockade combination cancer therapy gossypol metal-polyphenol coordination nanomedicine.
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	56435
Document Type	Journal article
Collection	DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Corresponding Author	Dai, Y.
Recommended Citation GB/T 7714	Zhang, Z.,Sang, W.,Xie, L.,et al. Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment[J]. Angewandte Chemie International Edition, 2021, 1967-1975.
APA	Zhang, Z.., Sang, W.., Xie, L.., Li, W.., Li, B.., Li, J.., Tian, H.., Yuan, Z.., Zhao, Q.., & Dai, Y. (2021). Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment. Angewandte Chemie International Edition, 1967-1975.
MLA	Zhang, Z.,et al."Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment".Angewandte Chemie International Edition (2021):1967-1975.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh