NIR-II-absorbing conjugated polymer-based theranostic agent for NIR-II fluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy

UM > Faculty of Health Sciences > DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION

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	NIR-II-absorbing conjugated polymer-based theranostic agent for NIR-II fluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy
	Li, J.; Xie, L.; Sang, W.; Li, W.; Wang, G.; Tian, H.; Zhang, Z.; Liu, J.; Fan, Q.; Dai, Y.
	2021-12-31
Source Publication	ChemPhysMater
ISSN	2097-0323
Pages	51-55
Abstract	Despite tremendous advances in gas therapy, there are major concerns about the inevitable concentration of toxicity and the ability to perform real-time tracking of drug delivery. Second near-infrared (NIR-II) window absorbing nanoplatforms hold great promise for precision medicine because of their excellent tissue penetration of light and non-invasive nature. In this study, we engineered an NIR-II laser-activated theranostic agent (named CP-bF@PEG) that was composed of amphiphilic polymers (Pluronic F127, with polyethylene glycol, PEG, moieties) coated with an NIR-II-absorbing conjugated polymer (PTTBBT, CP) and nitric oxide (NO) donor (benzofuroxan, bF), which served as an NIR-II photothermal inducer and NO nanogenerator. Under deep tissue penetration of NIR-II laser irradiation, CP-bF@PEG was found to possess fluorescence imaging ability to accurately identify tumor and excellent photothermal effect. Moreover, CP-bF@PEG could generate NO via glutathione activation in the tumor microenvironment in a controllable manner. This NIR-II-absorbing polymer for high-contrast NIR-II fluorescence imaging-guided precision photothermal therapy achieved synergistic effects with NO therapy, as evidenced by pronounced tumor therapeutic efficacy and few side effects. This nanotheranostic agent is a highly promising candidate for high-contrast NIR-II imaging-guided precision photothermal therapy combined with gas therapy against cancer.
Keyword	Conjugated polymer NIR-II fluorescence Photothermal therapy Tumor environment response Nitric oxide therapy
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	62874
Document Type	Journal article
Collection	DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Corresponding Author	Dai, Y.
Recommended Citation GB/T 7714	Li, J.,Xie, L.,Sang, W.,et al. NIR-II-absorbing conjugated polymer-based theranostic agent for NIR-II fluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy[J]. ChemPhysMater, 2021, 51-55.
APA	Li, J.., Xie, L.., Sang, W.., Li, W.., Wang, G.., Tian, H.., Zhang, Z.., Liu, J.., Fan, Q.., & Dai, Y. (2021). NIR-II-absorbing conjugated polymer-based theranostic agent for NIR-II fluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy. ChemPhysMater, 51-55.
MLA	Li, J.,et al."NIR-II-absorbing conjugated polymer-based theranostic agent for NIR-II fluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy".ChemPhysMater (2021):51-55.

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