Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy

UM > Faculty of Health Sciences > DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION

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	Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy
	Tian, H.; Wang, G.; Sang, w.; Xie, L.; Zhang, Z.; Li, W.; Yan, J.; Tian, Y.; Li, J.; Li, B.; Dai, Y.
	2022-01-25
Source Publication	Nano Today
ISSN	1748-0132
Pages	101405-101405
Abstract	Dendritic cells (DCs) play a key role in the presentation of tumor antigens to initiate innate and adaptive immune responses. While the tumor microenvironment (TME) contains a network of immunosuppressive factors that inhibit the differentiation and maturation of DCs. Immunoadjuvants have been focusing on modulating DCs function to improve cancer immunotherapy. Herein, a phenolic nanoadjuvant was developed by self-assembly of the sonosensitizer polymer (PEG-b-IR), GSH inhibitor (sabutoclax), Mn2+ and TME acidic sensitive phenolic polymer (PEG-b-Pho) via metal–phenolic coordination. The combinational action of SDT-mediated ICD effect and Mn2+ promoted the activation of the cGAS-STING pathway significantly enhanced DCs maturation. Furthermore, this phenolic nanoadjuvant greatly sensitizes tumors to PD-L1 checkpoint blockade immunotherapy, resulting in efficiently inhibiting the growth of distant tumors and restraining lung metastasis. Therefore, our work provides the potential to remedy the therapeutic limitation of insufficient antitumor immunity for enhanced cancer immunotherapy.
Keyword	Nanoadjuvant Sonodynamic therapy cGAS-STING pathway DCs maturation PD-L1 checkpoint blockade immunotherapy
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	62877
Document Type	Journal article
Collection	DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Corresponding Author	Dai, Y.
Recommended Citation GB/T 7714	Tian, H.,Wang, G.,Sang, w.,et al. Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy[J]. Nano Today, 2022, 101405-101405.
APA	Tian, H.., Wang, G.., Sang, w.., Xie, L.., Zhang, Z.., Li, W.., Yan, J.., Tian, Y.., Li, J.., Li, B.., & Dai, Y. (2022). Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy. Nano Today, 101405-101405.
MLA	Tian, H.,et al."Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy".Nano Today (2022):101405-101405.

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