| Residential College | false |
| Status | 已發表Published |
| The role of Raptor in lymphocytes differentiation and function | |
Tang,Jianing1; Yang,Lu1; Guan,Fei1; Miller,Heather2; Camara,Niels Olsen Saraiva3; James,Louisa K.4; Benlagha,Kamel5; Kubo,Masato6; Heegaard,Steffen7,8; Lee,Pamela9; Lei,Jiahui1; Zeng,Hu10,11; He,Chengwei12; Zhai,Zhimin13; Liu,Chaohong1
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| 2023 | |
| Source Publication | Frontiers in Immunology
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| ISSN | 1664-3224 |
| Volume | 14 |
| Abstract | Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation. |
| Keyword | b Cell Immune Mtorc1 Raptor t Cell |
| DOI | 10.3389/fimmu.2023.1146628 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Immunology |
| WOS Subject | Immunology |
| WOS ID | WOS:000999114300001 |
| Publisher | Frontiers Media S.A. |
| Scopus ID | 2-s2.0-85161006694 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Corresponding Author | Liu,Chaohong |
| Affiliation | 1.Department of Pathogen Biology,School of Basic Medicine,Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease,Huazhong University of Science and Technology,Wuhan,Hubei,China 2.Cytek Biosciences,R&D Clinical Reagents,Fremont,United States 3.Department of Immunology,Institute of Biomedical Sciences,University of São Paulo (USP),São Paulo,SP,Brazil 4.Centre for Immunobiology,Bizard Institute,Queen Mary University of London,London,United Kingdom 5.Université de Paris,Institut de Recherche Saint-Louis,EMiLy,Paris,France 6.Laboratory for Cytokine Regulation,Center for Integrative Medical Science (IMS),Rikagaku Kenkyusho,Institute of Physical and Chemical Research (RIKEN) Yokohama Institute,Yokohama,Japan 7.Department of Ophthalmology,Rigshospitalet Glostrup,Copenhagen,Denmark 8.Department of Clinical Medicine,University of Copenhagen,Copenhagen,Denmark 9.Department of Paediatrics and Adolescent Medicine,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 10.Department of Immunology,Mayo Clinic,Rochester,United States 11.Division of Rheumatology,Department of Medicine,Mayo Clinic,Rochester,United States 12.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao 13.Department of Hematology,The Second Hospital of Anhui Medical University,Hefei,China |
| Recommended Citation GB/T 7714 | Tang,Jianing,Yang,Lu,Guan,Fei,et al. The role of Raptor in lymphocytes differentiation and function[J]. Frontiers in Immunology, 2023, 14. |
| APA | Tang,Jianing., Yang,Lu., Guan,Fei., Miller,Heather., Camara,Niels Olsen Saraiva., James,Louisa K.., Benlagha,Kamel., Kubo,Masato., Heegaard,Steffen., Lee,Pamela., Lei,Jiahui., Zeng,Hu., He,Chengwei., Zhai,Zhimin., & Liu,Chaohong (2023). The role of Raptor in lymphocytes differentiation and function. Frontiers in Immunology, 14. |
| MLA | Tang,Jianing,et al."The role of Raptor in lymphocytes differentiation and function".Frontiers in Immunology 14(2023). |
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