Judging from the development status of most super-high-rise building industries in China, “outer frame + core tube” is basically adopted. The appearance of this core tube structure design concept puts forward higher requirements for the construction safety of the main structure. Combined with practical engineering projects, we analyze the safety risks and countermeasures of the outer frame column of the super high-rise steel structure, the safety risks and countermeasures of the cantilever steel beam, the safety risks and countermeasures of the waist truss, the safety risks and countermeasures of the waist truss, the safety risks and countermeasures of the outrigger truss, the safety risks and countermeasures of the tower crown structure are discussed one by one. It ensures the organic combination of engineering safety measures and engineering construction technology. The proposed safety measures are highly targeted and feasible, ensuring the safe construction of the project. The comprehensive application of this project confirms the feasibility of relevant countermeasures, so as to provide reference and help for subsequent similar projects.