Artificial intelligence (AI) has shown its effectiveness in helping clinical users meet evolving challenges. Recently, ChatGPT, a newly launched AI chatbot with exceptional text comprehension capabilities, has triggered a global wave of AI popularization and application in seeking answers through human‒machine dialogues. Gastric cancer, as a globally prevalent disease, has a five-year survival rate of up to 90% when detected early and treated promptly. This research aims to explore ChatGPT's potential in disseminating gastric cancer knowledge, providing consultation recommendations, and interpreting endoscopy reports. Through experimentation, the GPT-4 model of ChatGPT achieved an appropriateness of 91.3% and a consistency of 95.7% in a gastric cancer knowledge test. Furthermore, GPT-4 has demonstrated considerable potential in consultation recommendations and endoscopy report analysis.