Residential College | false |
Status | 已發表Published |
Transfer learning-based attenuation correction for static and dynamic cardiac PET using a generative adversarial network | |
Hao Sun1,2,3,4; Fanghu Wang5; Yuling Yang1,3,4; Xiaotong Hong1,3,4; Weiping Xu5; Shuxia Wang5; Greta S. P. Mok2; Lijun Lu1,3,4,6 | |
2023-07-21 | |
Source Publication | European Journal of Nuclear Medicine and Molecular Imaging |
ISSN | 1619-7070 |
Volume | 50Issue:12Pages:3630-3646 |
Abstract | Purpose: The goal of this work is to demonstrate the feasibility of directly generating attenuation-corrected PET images from non-attenuation-corrected (NAC) PET images for both rest and stress-state static or dynamic [N]ammonia MP PET based on a generative adversarial network. Methods: We recruited 60 subjects for rest-only scans and 14 subjects for rest-stress scans, all of whom underwent [N]ammonia cardiac PET/CT examinations to acquire static and dynamic frames with both 3D NAC and CT-based AC (CTAC) PET images. We developed a 3D pix2pix deep learning AC (DLAC) framework via a U-net + ResNet-based generator and a convolutional neural network-based discriminator. Paired static or dynamic NAC and CTAC PET images from 60 rest-only subjects were used as network inputs and labels for static (S-DLAC) and dynamic (D-DLAC) training, respectively. The pre-trained S-DLAC network was then fine-tuned by paired dynamic NAC and CTAC PET frames of 60 rest-only subjects to derive an improved D-DLAC-FT for dynamic PET images. The 14 rest-stress subjects were used as an internal testing dataset and separately tested on different network models without training. The proposed methods were evaluated using visual quality and quantitative metrics. Results: The proposed S-DLAC, D-DLAC, and D-DLAC-FT methods were consistent with clinical CTAC in terms of various images and quantitative metrics. The S-DLAC (slope = 0.9423, R = 0.947) showed a higher correlation with the reference static CTAC as compared to static NAC (slope = 0.0992, R = 0.654). D-DLAC-FT yielded lower myocardial blood flow (MBF) errors in the whole left ventricular myocardium than D-DLAC, but with no significant difference, both for the 60 rest-state subjects (6.63 ± 5.05% vs. 7.00 ± 6.84%, p = 0.7593) and the 14 stress-state subjects (1.97 ± 2.28% vs. 3.21 ± 3.89%, p = 0.8595). Conclusion: The proposed S-DLAC, D-DLAC, and D-DLAC-FT methods achieve comparable performance with clinical CTAC. Transfer learning shows promising potential for dynamic MP PET. |
Keyword | Attenuation Correction Deep Learning Myocardial Blood Flow Myocardial Perfusion Pet Transfer Learning |
DOI | 10.1007/s00259-023-06343-9 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Radiology, Nuclear Medicine & Medical Imaging |
WOS Subject | Radiology, Nuclear Medicine & Medical Imaging |
WOS ID | WOS:001032732600002 |
Publisher | SPRINGERONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATES |
Scopus ID | 2-s2.0-85165187635 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Faculty of Science and Technology DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING |
Corresponding Author | Shuxia Wang; Greta S. P. Mok; Lijun Lu |
Affiliation | 1.School of Biomedical Engineering,Southern Medical University,Guangzhou,1023 Shatai Road,510515,China 2.Biomedical Imaging Laboratory (BIG),Department of Electrical and Computer Engineering,Faculty of Science and Technology,University of Macau,Taipa,SAR,Macao 3.Guangdong Provincial Key Laboratory of Medical Image Processing,Southern Medical University,Guangzhou,1023 Shatai Road,510515,China 4.Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology,Southern Medical University,Guangzhou,1023 Shatai Road,510515,China 5.PET Center,Department of Nuclear Medicine,Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou,China 6.Pazhou Lab,Guangzhou,510330,China |
First Author Affilication | Faculty of Science and Technology |
Corresponding Author Affilication | Faculty of Science and Technology |
Recommended Citation GB/T 7714 | Hao Sun,Fanghu Wang,Yuling Yang,et al. Transfer learning-based attenuation correction for static and dynamic cardiac PET using a generative adversarial network[J]. European Journal of Nuclear Medicine and Molecular Imaging, 2023, 50(12), 3630-3646. |
APA | Hao Sun., Fanghu Wang., Yuling Yang., Xiaotong Hong., Weiping Xu., Shuxia Wang., Greta S. P. Mok., & Lijun Lu (2023). Transfer learning-based attenuation correction for static and dynamic cardiac PET using a generative adversarial network. European Journal of Nuclear Medicine and Molecular Imaging, 50(12), 3630-3646. |
MLA | Hao Sun,et al."Transfer learning-based attenuation correction for static and dynamic cardiac PET using a generative adversarial network".European Journal of Nuclear Medicine and Molecular Imaging 50.12(2023):3630-3646. |
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