| Residential College | false |
| Status | 已發表Published |
| The emerging mechanisms and functions of microautophagy | |
Wang，Liming1; Klionsky，Daniel J.2 ; Shen，Han Ming3,4
| |
| 2023-03-01 | |
| Source Publication | Nature Reviews Molecular Cell Biology
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| ISSN | 1471-0072 |
| Volume | 24Issue:3Pages:186-203 |
| Abstract | ‘Autophagy’ refers to an evolutionarily conserved process through which cellular contents, such as damaged organelles and protein aggregates, are delivered to lysosomes for degradation. Different forms of autophagy have been described on the basis of the nature of the cargoes and the means used to deliver them to lysosomes. At present, the prevailing categories of autophagy in mammalian cells are macroautophagy, microautophagy and chaperone-mediated autophagy. The molecular mechanisms and biological functions of macroautophagy and chaperone-mediated autophagy have been extensively studied, but microautophagy has received much less attention. In recent years, there has been a growth in research on microautophagy, first in yeast and then in mammalian cells. Here we review this form of autophagy, focusing on selective forms of microautophagy. We also discuss the upstream regulatory mechanisms, the crosstalk between macroautophagy and microautophagy, and the functional implications of microautophagy in diseases such as cancer and neurodegenerative disorders in humans. Future research into microautophagy will provide opportunities to develop novel interventional strategies for autophagy- and lysosome-related diseases. |
| DOI | 10.1038/s41580-022-00529-z |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85137899427 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Faculty of Health Sciences DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Klionsky，Daniel J. |
| Affiliation | 1.School of Biomedical Sciences,Hunan University,Changsha,China 2.Life Sciences Institute and Department of Molecular,Cellular and Developmental Biology,University of Michigan,Ann Arbor,United States 3.Faculty of Health Sciences,Ministry of Education Frontiers Science Center for Precision Oncology,University of Macau,Macao 4.Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore |
| Recommended Citation GB/T 7714 | Wang，Liming,Klionsky，Daniel J.,Shen，Han Ming. The emerging mechanisms and functions of microautophagy[J]. Nature Reviews Molecular Cell Biology, 2023, 24(3), 186-203. |
| APA | Wang，Liming., Klionsky，Daniel J.., & Shen，Han Ming (2023). The emerging mechanisms and functions of microautophagy. Nature Reviews Molecular Cell Biology, 24(3), 186-203. |
| MLA | Wang，Liming,et al."The emerging mechanisms and functions of microautophagy".Nature Reviews Molecular Cell Biology 24.3(2023):186-203. |
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