The proactive development in electronic health (e-health) has introduced seemingly endless number of applications such as telemedicine, electronic records, healthcare score cards, healthcare monitoring etc. Yet, these applications confront the key challenges of network dependence and medical personnel necessity, which hinders the development of universality of e-health services. To mitigate such key challenges, this chapter presents a versatile wired and wireless distributed e-home healthcare system. By exploiting the benefit of body sensor network and information communication technology, the dedicated system model methodically integrates some of the comprehensive functions such as pervasive health monitoring, remote healthcare data access, point-of-care signal interpretation and diagnosis, disease-driven uplink update and synchronization (UUS) scheme and emergency management to design a complete and independent e-home healthcare system.