Residential College | false |
Status | 已發表Published |
How efficacious are traditional Chinese medicine injections in treating angina pectoris? A network meta-analysis of randomized controlled trials | |
Jia, Yongliang1,2; Gao, Guoying2; Leung, Siu wai2,3,4 | |
2022-12-09 | |
Source Publication | Journal of Ethnopharmacology |
ISSN | 0378-8741 |
Volume | 303Pages:115996 |
Abstract | Ethnopharmacological relevance: Over 50 million adults in China suffer from angina pectoris, which are often treated with traditional Chinese medicine injections (TCMIs). However, the efficacies of TCMIs and conventional drugs as determined by randomized controlled trials (RCTs) were not rigorously compared with one another by network meta-analysis (NMA). This PRISMA-compliant NMA aimed to compare the efficacy and assess the evidence strengths of 24 TCMIs in treating adults with angina pectoris of RCTs. Materials and methods: Following the protocol (PROSPERO registration number CRD42018117720), the RCTs that compared any TCMI with another TCMI or conventional drug on outcome measures including symptomatic and electrocardiography improvements were included. The quality of included RCTs was assessed with the Cochrane's risk of bias 2 tool. Frequentist statistical analyses were performed, including NMA, pairwise meta-analysis (PMA), subgroup analysis, sensitivity analysis, meta-regression, and publication bias analysis. The certainty of evidence was assessed with the GRADE approach. Results: Totally, 556 eligible RCTs with 57015 participants were identified while the quality of all but five included RCTs was poor. The significant efficacy estimates and insignificant heterogeneity assessment from PMA and NMA indicated that nearly all TCMIs were more efficacious than conventional treatments for angina pectoris. Adequate subgroup and sensitivity analyses found the robust and consistent results. However, the evidence strengths of meta-analyses were assessed as very low to low due to the high risk of RCTs. The comprehensive efficacy estimates suggested that 4 TCMIs (HH, Honghua injection; HHH, Honghua Huangsesu injection; GLP, Gualoupi injection; and SM, Shenmai injection) was the best anti-anginal drugs for adults with angina pectoris. Conclusion: TCMIs appear to be efficacious for angina pectoris, although evidence evaluation of high-quality RCTs of TCMIs would be necessary. In particular, randomization and blinding procedures of the RCTs should be explicated to meet the CONSORT requirements. |
Keyword | Angina Pectoris Evidence Strengths Network Meta-analysis Randomized Controlled Trials Traditional Chinese Medicine Injection |
DOI | 10.1016/j.jep.2022.115996 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
WOS Subject | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
WOS ID | WOS:000920641900001 |
Publisher | ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE 00000, IRELAND |
Scopus ID | 2-s2.0-85144638197 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) |
Co-First Author | Jia, Yongliang |
Corresponding Author | Jia, Yongliang |
Affiliation | 1.BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 3.Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China 4.Edinburgh Bayes Centre for AI Research in Shenzhen, College of Science and Engineering, University of Edinburgh, Scotland, United Kingdom |
First Author Affilication | Institute of Chinese Medical Sciences |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Jia, Yongliang,Gao, Guoying,Leung, Siu wai. How efficacious are traditional Chinese medicine injections in treating angina pectoris? A network meta-analysis of randomized controlled trials[J]. Journal of Ethnopharmacology, 2022, 303, 115996. |
APA | Jia, Yongliang., Gao, Guoying., & Leung, Siu wai (2022). How efficacious are traditional Chinese medicine injections in treating angina pectoris? A network meta-analysis of randomized controlled trials. Journal of Ethnopharmacology, 303, 115996. |
MLA | Jia, Yongliang,et al."How efficacious are traditional Chinese medicine injections in treating angina pectoris? A network meta-analysis of randomized controlled trials".Journal of Ethnopharmacology 303(2022):115996. |
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