Residential College | false |
Status | 已發表Published |
Development and validation of the Chinese Geriatric Depression Risk calculator (CGD-risk): A screening tool to identify elderly Chinese with depression | |
Collin Sakal1; Juan Li2; Yu-Tao Xiang3![]() ![]() | |
2022-12-15 | |
Source Publication | JOURNAL OF AFFECTIVE DISORDERS
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ISSN | 0165-0327 |
Volume | 319Pages:428-436 |
Abstract | Background: The prevalence of depression among China's elderly is high, but stigma surrounding mental illness and a shortage of psychiatrists limit widespread screening and diagnosis of geriatric depression. We sought to develop a screening tool using easy-to-obtain and minimally sensitive predictors to identify elderly Chinese with depressive symptoms (depression hereafter) for referral to mental health services and determine the most important factors for effective screening. Methods: Using nationally representative survey data, we developed and externally validated the Chinese Geriatric Depression Risk calculator (CGD-Risk). CGD-Risk, a gradient boosting machine learning model, was evaluated based on discrimination (Concordance (C) statistic), calibration, and through a decision curve analysis. We conducted a sensitivity analysis on a cohort of middle-aged Chinese, a sub-group analysis using three data sets, and created predictor importance and partial dependence plots to enhance interpretability. Results: A total of 5681 elderly Chinese were included in the development data and 12,373 in the external validation data. CGD-Risk showed good discrimination during internal validation (C: 0.81, 95 % CI 0.79 to 0.84) and external validation (C: 0.77, 95 % CI: 0.76, 0.78). Compared to an alternative screening strategy CGD-Risk would correctly identify 17.8 more elderly with depression per 100 people screened. Limitations: We were only able to externally validate a partial version of CGD-Risk due to differences between the internal and external validation data. Conclusions: CGD-Risk is a clinically viable, minimally sensitive screening tool that could identify elderly Chinese at high risk of depression while circumventing issues of response bias from stigma surrounding emotional openness. |
Keyword | Depression Machine Learning Prediction China Geriatrics |
DOI | 10.1016/j.jad.2022.09.034 |
URL | View the original |
Indexed By | SCIE ; SSCI |
Language | 英語English |
WOS Research Area | Neurosciences & Neurology ; Psychiatry |
WOS Subject | Clinical Neurology ; Psychiatry |
WOS ID | WOS:000870046800005 |
Publisher | ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS |
Scopus ID | 2-s2.0-85138800399 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION Faculty of Health Sciences Institute of Translational Medicine |
Corresponding Author | Xinyue Li |
Affiliation | 1.School of Data Science, City University of Hong Kong, Hong Kong, SAR, China 2.Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China 3.Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China |
Recommended Citation GB/T 7714 | Collin Sakal,Juan Li,Yu-Tao Xiang,et al. Development and validation of the Chinese Geriatric Depression Risk calculator (CGD-risk): A screening tool to identify elderly Chinese with depression[J]. JOURNAL OF AFFECTIVE DISORDERS, 2022, 319, 428-436. |
APA | Collin Sakal., Juan Li., Yu-Tao Xiang., & Xinyue Li (2022). Development and validation of the Chinese Geriatric Depression Risk calculator (CGD-risk): A screening tool to identify elderly Chinese with depression. JOURNAL OF AFFECTIVE DISORDERS, 319, 428-436. |
MLA | Collin Sakal,et al."Development and validation of the Chinese Geriatric Depression Risk calculator (CGD-risk): A screening tool to identify elderly Chinese with depression".JOURNAL OF AFFECTIVE DISORDERS 319(2022):428-436. |
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