We present green organohydrogel-based stretchable (up to 700% strain), transparent, and room-temperature O sensors with impressive performance, including drying and freezing tolerances, high sensitivity, broad detection range (100 ppm-100%), long-term stability, low theoretical detection limit (0.585 ppm), linearity, and the capability to real-time monitor human respiration by directly attaching on human skin. A facile solvent replacement approach is employed to partially exchange water with natural and edible xylitol/sorbitol molecules, generating stable, green and tough organohydrogels. Compared with the pristine hydrogel counterpart, the organohydrogel-based O sensors feature higher stability, prolonged life time (140 days) and the ability to work over a wide range of temperatures (−38 to 65°C). The O sensing mechanism is elucidated by investigating the redox reactions occurred at the electrode-hydrogel interface. This work develops a facile strategy to fabricate stretchable, transparent, and high-performance O sensor using stable and green organohydrogels as novel transducing materials for practical wearable applications. (Figure presented.).