| Residential College | false |
| Status | 已發表Published |
| A new polysaccharide from Caulerpa chemnitzia induces molecular shifts of immunomodulation on macrophages RAW264.7 | |
Wu, Yulin1; Liu, Jun2; Hao, Huili1; Hu, Lianmei3; Zhang, Xiaoyong4; Luo, Lianxiang2; Zeng, Jincheng2; Zhang, Wei5; Nam Wong, Io5; Huang, Riming1
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| 2022-06-30 | |
| Source Publication | Food Chemistry: X
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| ISSN | 2590-1575 |
| Volume | 14 |
| Abstract | Investigation on Caulerpa chemnitzia polysaccharides led to the finding of a new polysaccharide (CCP). The basic components of CCP were the total sugar (59.18% ± 0.57%), the uronic acids (36.75% ± 0.28%) and the sulfate (42.50% ± 0.42%), in total content. The physicochemical analysis revealed that CCP was a heteropolysaccharide with a molecular weight of 321.6 KDa, and composed of arabinose, fucose, glucose, mannose, galactose, xylose, fructose, ribose, glucuronic acid and galacturonic acid. The immunomodulatory assay showed that CCP played an important role in activating cell viability, the nitric oxide product and cytokines (IL-6 and TNF-α) secretion. Furthermore, the transcript-metabolic analysis displayed a total of 7692 differentially expressed genes (DEGs) and 95 differentially accumulated metabolites (DAMs), and revealed that CCP may play an immunomodulatory effect by activating NF-κB signaling pathway and arachidonic acid metabolism pathway. These findings will provide a basic understanding to further investigation of Caulerpa polysaccharides. |
| Keyword | Arachidonic Acid Metabolism Pathway Caulerpa Chemnitzia Immunomodulatory Effect Nf-κb Signaling Pathway Polysaccharide Transcript-metabolic Analysis |
| DOI | 10.1016/j.fochx.2022.100313 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Chemistry ; Food Science & Technology |
| WOS Subject | Chemistry, Applied ; Food Science & Technology |
| WOS ID | WOS:000796187900004 |
| Publisher | ELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS |
| Scopus ID | 2-s2.0-85129682159 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Corresponding Author | Huang, Riming |
| Affiliation | 1.Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China 2.Laboratory of Pathogenic Biology, The Marine Biomedical Research Institute, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Zhanjiang, Guangdong, 524023, China 3.College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China 4.Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China 5.State Key Laboratory of Quality Research in Chinese Medicines and Macau Institute for Applied Research in Medicine and Health, Faculty of Medicine, Macau University of Science and Technology, Taipa, Macau, 999078, China |
| Recommended Citation GB/T 7714 | Wu, Yulin,Liu, Jun,Hao, Huili,et al. A new polysaccharide from Caulerpa chemnitzia induces molecular shifts of immunomodulation on macrophages RAW264.7[J]. Food Chemistry: X, 2022, 14. |
| APA | Wu, Yulin., Liu, Jun., Hao, Huili., Hu, Lianmei., Zhang, Xiaoyong., Luo, Lianxiang., Zeng, Jincheng., Zhang, Wei., Nam Wong, Io., & Huang, Riming (2022). A new polysaccharide from Caulerpa chemnitzia induces molecular shifts of immunomodulation on macrophages RAW264.7. Food Chemistry: X, 14. |
| MLA | Wu, Yulin,et al."A new polysaccharide from Caulerpa chemnitzia induces molecular shifts of immunomodulation on macrophages RAW264.7".Food Chemistry: X 14(2022). |
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