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Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy
Dongbo Guo1,2; Josh Haipeng Lei3,4; Dade Rong3; Tesen Zhang1; Bohan Zhang1; Zikang Tang1,4,5; Han-Ming Shen3,4; Chu-Xia Deng3,4; Songnan Qu1,4,5
2022-12-28
Source PublicationAdvanced Science
ISSN2198-3844
Volume9Issue:36
Abstract

Rapid, efficient, and precise cancer therapy is highly desired. Here, this work reports solvothermally synthesized photoactivatable Pt(IV)-coordinated carbon dots (Pt-CDs) and their bovine serum albumin (BSA) complex (Pt-CDs@BSA) as a novel orange light-triggered anti-tumor therapeutic agent. The homogeneously distributed Pt(IV) in the Pt-CDs (Pt: 17.2 wt%) and their carbon cores with significant visible absorption exhibit excellent photocatalytic properties, which not only efficiently releases cytotoxic Pt(II) species but also promotes hydroxy radical generation from water under orange light. When triggered with a 589 nm laser, Pt-CDs@BSA possesses the ultrastrong cancer cell killing capacities of intracellular Pt(II) species release, hydroxyl radical generation, and acidification, which induce powerful immunogenic cell death. Activation of Pt-CDs@BSA by a single treatment with a 589 nm laser effectively eliminated the primary tumor and inhibited distant tumor growth and lung metastasis. This study thus presents a new concept for building photoactivatable Pt(IV)-enriched nanodrug-based CDs for precision cancer therapy.

KeywordCarbon Dots Immunogenetic Cell Death Photocatalyst Pt(Iv) Enriched Prodrug Tumor Therapy
DOI10.1002/advs.202205106
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science
WOS IDWOS:000875462600001
PublisherWILEY111 RIVER ST, HOBOKEN 07030-5774, NJ
Scopus ID2-s2.0-85141395585
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Document TypeJournal article
CollectionMinistry of Education Frontiers Science Center for Precision Oncology, University of Macau
Faculty of Health Sciences
INSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING
Corresponding AuthorHan-Ming Shen; Chu-Xia Deng; Songnan Qu
Affiliation1.Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macao
2.School of Biomedical Engineering, State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, 570228, China
3.Faculty of Health Sciences, University of Macau, Taipa, Macao
4.MOE Frontier Science Centre for Precision Oncology, Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macao
5.Department of Physics and Chemistry, University of Macau, Taipa, SAR, Macao
First Author AffilicationINSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING
Corresponding Author AffilicationFaculty of Health Sciences;  Cancer Centre;  INSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING;  University of Macau
Recommended Citation
GB/T 7714
Dongbo Guo,Josh Haipeng Lei,Dade Rong,et al. Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy[J]. Advanced Science, 2022, 9(36).
APA Dongbo Guo., Josh Haipeng Lei., Dade Rong., Tesen Zhang., Bohan Zhang., Zikang Tang., Han-Ming Shen., Chu-Xia Deng., & Songnan Qu (2022). Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy. Advanced Science, 9(36).
MLA Dongbo Guo,et al."Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy".Advanced Science 9.36(2022).
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