Residential College | false |
Status | 已發表Published |
Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy | |
Dongbo Guo1,2; Josh Haipeng Lei3,4; Dade Rong3; Tesen Zhang1; Bohan Zhang1; Zikang Tang1,4,5; Han-Ming Shen3,4; Chu-Xia Deng3,4; Songnan Qu1,4,5 | |
2022-12-28 | |
Source Publication | Advanced Science |
ISSN | 2198-3844 |
Volume | 9Issue:36 |
Abstract | Rapid, efficient, and precise cancer therapy is highly desired. Here, this work reports solvothermally synthesized photoactivatable Pt(IV)-coordinated carbon dots (Pt-CDs) and their bovine serum albumin (BSA) complex (Pt-CDs@BSA) as a novel orange light-triggered anti-tumor therapeutic agent. The homogeneously distributed Pt(IV) in the Pt-CDs (Pt: 17.2 wt%) and their carbon cores with significant visible absorption exhibit excellent photocatalytic properties, which not only efficiently releases cytotoxic Pt(II) species but also promotes hydroxy radical generation from water under orange light. When triggered with a 589 nm laser, Pt-CDs@BSA possesses the ultrastrong cancer cell killing capacities of intracellular Pt(II) species release, hydroxyl radical generation, and acidification, which induce powerful immunogenic cell death. Activation of Pt-CDs@BSA by a single treatment with a 589 nm laser effectively eliminated the primary tumor and inhibited distant tumor growth and lung metastasis. This study thus presents a new concept for building photoactivatable Pt(IV)-enriched nanodrug-based CDs for precision cancer therapy. |
Keyword | Carbon Dots Immunogenetic Cell Death Photocatalyst Pt(Iv) Enriched Prodrug Tumor Therapy |
DOI | 10.1002/advs.202205106 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science |
WOS Subject | Chemistry ; Science & Technology - Other Topics ; Materials Science |
WOS ID | WOS:000875462600001 |
Publisher | WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ |
Scopus ID | 2-s2.0-85141395585 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau Faculty of Health Sciences INSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING |
Corresponding Author | Han-Ming Shen; Chu-Xia Deng; Songnan Qu |
Affiliation | 1.Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macao 2.School of Biomedical Engineering, State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, 570228, China 3.Faculty of Health Sciences, University of Macau, Taipa, Macao 4.MOE Frontier Science Centre for Precision Oncology, Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macao 5.Department of Physics and Chemistry, University of Macau, Taipa, SAR, Macao |
First Author Affilication | INSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING |
Corresponding Author Affilication | Faculty of Health Sciences; Cancer Centre; INSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING; University of Macau |
Recommended Citation GB/T 7714 | Dongbo Guo,Josh Haipeng Lei,Dade Rong,et al. Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy[J]. Advanced Science, 2022, 9(36). |
APA | Dongbo Guo., Josh Haipeng Lei., Dade Rong., Tesen Zhang., Bohan Zhang., Zikang Tang., Han-Ming Shen., Chu-Xia Deng., & Songnan Qu (2022). Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy. Advanced Science, 9(36). |
MLA | Dongbo Guo,et al."Photocatalytic Pt(IV)-Coordinated Carbon Dots for Precision Tumor Therapy".Advanced Science 9.36(2022). |
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