Absent angiogenesis and bacterial infection are two major challenges that simultaneously delay the repair of injured tissues and organs. However, most current therapeutic systems deliver therapeutic cues in a separate and inaccurate manner which stimulates angiogenesis or inhibits infection leading to limited repair and side effects. Advanced therapeutic systems capable of providing accurate angiogenic stimulation and anti-infection signals in response to the changing microenvironment are urgently needed. Herein, a nano-reactor (ZFVO) involving zeolitic imidazolate framework-67 (ZIF-67)-deposited hollow vanadium oxide (VO) is developed to intelligently execute pro-angiogenesis and/or disinfection via the responsive release of cobalt ions and hydroxyl radicals to the injury and infection sites, respectively. ZFVO nano-reactor demonstrates a novel strategy for constructing drug-free nano-platforms with a hierarchical structure which has potential for the accurate treatment of trauma and orthopedic diseases.