| Residential College | false |
| Status | 已發表Published |
| Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications | |
Gu, Junling1,2,3; Geng, Kang1,2,4; Guo, Man2; Huang, Wei2; Zhao, Tingting1; Li, Xuling1; Xu, You Hua1 ; Xu, Yong1,2
| |
| 2022 | |
| Source Publication | Evidence-based Complementary and Alternative Medicine
 |
| ISSN | 1741-427X |
| Volume | 2022 |
| Abstract | Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1β and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptosis, and different signaling pathways have been shown to play crucial roles in regulating pyroptosis. This review summarized and discussed the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. In addition, this review aimed to provide new insights into identifying better treatments for diabetic microvascular complications. |
| DOI | 10.1155/2022/5277673 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Integrative & Complementary Medicine |
| WOS Subject | Integrative & Complementary Medicine |
| WOS ID | WOS:000868325700011 |
| Publisher | HINDAWI LTDADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON W1T 5HF, ENGLAND |
| Scopus ID | 2-s2.0-85139760473 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Corresponding Author | Xu, You Hua; Xu, Yong |
| Affiliation | 1.Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Avenida Wai Long, Macao 2.Department of Endocrinology and Metabolism, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Nephropathy, Cardiovascular and Metabolic Diseases, Key Laboratory of Luzhou, Luzhou, Hubei, China 3.Department of Endocrinology, The Second People's Hospital of Yibin City-West China Yibin Hospital, Sichuan Univerity, Yibin, Sichuan, China 4.Department of Plastic and Burn Surgery, National Key Clinical Construction Specialty, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China |
| First Author Affilication | University of Macau |
| Corresponding Author Affilication | University of Macau |
| Recommended Citation GB/T 7714 | Gu, Junling,Geng, Kang,Guo, Man,et al. Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications[J]. Evidence-based Complementary and Alternative Medicine, 2022, 2022. |
| APA | Gu, Junling., Geng, Kang., Guo, Man., Huang, Wei., Zhao, Tingting., Li, Xuling., Xu, You Hua., & Xu, Yong (2022). Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications. Evidence-based Complementary and Alternative Medicine, 2022. |
| MLA | Gu, Junling,et al."Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications".Evidence-based Complementary and Alternative Medicine 2022(2022). |
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