The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications

doi:10.1016/j.gendis.2022.10.017

Status	即將出版Forthcoming
	The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications
	Huang, Dan 1,2; Liu, Gege 1; Xu, Zhiyi 1; Chen, Shushu 1; Wang, Cuili 1; Liu, Dewei 1; Cao, Jiahao 1; Cheng, Junfen 3; Wu, Bin 1; Wu, Dong 1
	2022
Source Publication	Genes and Diseases
Abstract	Placental growth factor (PlGF) is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor (VEGF). PlGF expression is upregulated in patients with bronchial asthma, suggesting that it plays a role in the pathogenesis of asthma. Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness (AHR). After recurrent asthma attacks, pulmonary fibrosis develops and leads to airway remodeling and a further decline in lung function. In this review, we focused on the pivotal role of PlGF in chronic airway inflammation, AHR, and airway remodeling during bronchial asthma. Furthermore, we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma.
Keyword	AHR Airway remodeling Bronchial asthma Chronic airway inflammation PlGF
DOI	10.1016/j.gendis.2022.10.017
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85143588074
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
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Document Type	Journal article
Collection	University of Macau
Affiliation	1.Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524000, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Avenida Wai Long, Macao SAR, 999078, China 3.Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524000, China
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Huang, Dan,Liu, Gege,Xu, Zhiyi,et al. The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications[J]. Genes and Diseases, 2022.
APA	Huang, Dan., Liu, Gege., Xu, Zhiyi., Chen, Shushu., Wang, Cuili., Liu, Dewei., Cao, Jiahao., Cheng, Junfen., Wu, Bin., & Wu, Dong (2022). The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications. Genes and Diseases.
MLA	Huang, Dan,et al."The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications".Genes and Diseases (2022).

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