This article describes a miniaturized 3-D magnetic resonance imaging (3-D-MRI) scanner empowered by a high-voltage silicon-on-insulator (HV-SOI) CMOS application-specific integrated circuit (ASIC). With a 0.52-T permanent magnet and integrating the electronics onto a 6-mm ² silicon chip, the scanner weighs 42 kg and provides a field of view (FOV) of 10 × 8 × 8 mm ³ for probing the internal structure of a wide variety of objects non-invasively. The ASIC features a mixed-transistor HV-enabled transmitter (TX) to enhance the output-current deliverability (1.24 App to a 1- Ω load), a low-noise receiver (RX) exploiting the dynamic-threshold MOSFET (DTMOS), and deep trench isolation (DTI) for a better noise performance and substrate noise immunity. The achieved RX input-referred noise of 0.63 nV/ √ Hz significantly enhances the SNR of the image and enables fast image acquisition. We also introduce a digital-to-analog converter (DAC)-based gradient controller to compose the MRI sequences for 3-D spatial encoding. The key functionality of the 3-D-MRI scanner is exhibited with two fruit samples: raspberry and pomegranate, achieving a resolution of 110 × 117 × 250 μm3 , in 0.17 min.