Research progress on immunosuppressive mechanism of sinomenine 青藤碱免疫抑制作用机制的研究进展

doi:10.7501/j.issn.0253-2670.2022.01.030

Status	即將出版Forthcoming
	Research progress on immunosuppressive mechanism of sinomenine 青藤碱免疫抑制作用机制的研究进展
	Huang, Hong 1; Hu, Ming Yue 1; Xu, Li 1; Yi, Ou Yang 1; Su, Zhao Li 1; Lin, Ye 1; Zhang, Feng 1; Qiu, Feng 1; Huang, Yu Ming 2; Zhou, Hua 3; Liu, Liang 3; Cai, Xiong 1
	2022-01-12
Source Publication	Chinese Traditional and Herbal Drugs
ISSN	0253-2670
Volume	53 Issue:1 Pages:261-269
Abstract	Sinomenine is a main bioactive alkaloid isolated from the stem of Sinomenium acutum. Sinomenine demonstrates significant analgesic, anti-inflammatory, and immunosuppressive effects, and has presented great potential as a naturally-derived immunosuppressive agent for autoimmune diseases. Many researches have shown that sinomenine exerts its immunosuppressive effects on various immune cells (T cells, monocytes/macrophages, dendritic cells and mast cells) and a number of immune response related factors (cytokines, reactive oxygen, nuclear factor-κB and cell adhesion molecules). Research progress on immunosuppressive mechanism of sinomenine are reviewed in this paper, so as to provide research ideas for identification of immunosuppressive target and signaling pathway of sinomenine as a treatment for autoimmune diseases.
Keyword	Autoimmune disease Immune cell Immune response related factor Immunosuppression Sinomenine Sinomenium acutum (Thunb.) Rehd. et Wils.
DOI	10.7501/j.issn.0253-2670.2022.01.030
URL	View the original
Language	中文Chinese
Scopus ID	2-s2.0-85122203089
Fulltext Access	View Full-Text via DOI View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese, Changsha, 410208, China 2.Hunan Zhengqing Pharmaceutical Group Co., Ltd., Huaihua, 418000, China 3.State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, 999078, Macao
Recommended Citation GB/T 7714	Huang, Hong,Hu, Ming Yue,Xu, Li,等. Research progress on immunosuppressive mechanism of sinomenine 青藤碱免疫抑制作用机制的研究进展[J]. Chinese Traditional and Herbal Drugs, 2022, 53(1), 261-269.
APA	Huang, Hong., Hu, Ming Yue., Xu, Li., Yi, Ou Yang., Su, Zhao Li., Lin, Ye., Zhang, Feng., Qiu, Feng., Huang, Yu Ming., Zhou, Hua., Liu, Liang., & Cai, Xiong (2022). Research progress on immunosuppressive mechanism of sinomenine 青藤碱免疫抑制作用机制的研究进展. Chinese Traditional and Herbal Drugs, 53(1), 261-269.
MLA	Huang, Hong,et al."Research progress on immunosuppressive mechanism of sinomenine 青藤碱免疫抑制作用机制的研究进展".Chinese Traditional and Herbal Drugs 53.1(2022):261-269.

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