| Status | 已發表Published |
| The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression | |
| Chou, C. K. | |
| 2017-12-05 | |
| Source Publication | Archivum Immunologiae et Therapiae Experimentalis
 |
| ISSN | doi: 10.1007/s00005-017-0494-2. |
| Pages | 183-197 |
| Abstract | Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks for human populations exposed to DEHP has been assumed by studies on rodents and other species, including the DEHP-induced developmental dysregulation, reproductive impairments, tumorigenesis, and diseases in a transgenerational manner. In this review, we comprehensively summarize the accumulated literature regarding the multifaceted roles of DEHP in the activation of the nuclear receptors, the alteration of the redox homeostasis, epigenetic modifications and the acquisition of chemoresistance. |
| Keyword | Chemoresistance DEHP Epigenetic modifications Nuclear receptors Redox homeostasis Tumorigenesis. |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 54484 |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Chou, C. K.. The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression[J]. Archivum Immunologiae et Therapiae Experimentalis, 2017, 183-197. |
| APA | Chou, C. K..(2017). The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression. Archivum Immunologiae et Therapiae Experimentalis, 183-197. |
| MLA | Chou, C. K.."The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression".Archivum Immunologiae et Therapiae Experimentalis (2017):183-197. |
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