| Residential College | true |
| Status | 已發表Published |
| Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy | |
Yizhou Jiang1; Limor Rubin, MD2; Tangming Peng1; Linlin Liu1; Xingan Xing1; Philip Lazarovici3; Zheng WH(鄭文華)1
| |
| 2022 | |
| Source Publication | International Journal of Biological Sciences
 |
| ISSN | 1449-2288 |
| Volume | 2022Issue:18Pages:459-472 |
| Abstract | The COVID-19 outbreak is emerging as a significant public health challenge. Excessive production of
proinflammatory cytokines, also known as cytokine storm, is a severe clinical syndrome known to
develop as a complication of infectious or inflammatory diseases. Clinical evidence suggests that the
occurrence of cytokine storm in severe acute respiratory syndrome secondary to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely associated with the rapid
deterioration and high mortality of severe cases. In this review, we aim to summarize the mechanism of
SARS-CoV-2 infection and the subsequent immunological events related to excessive cytokine
production and inflammatory responses associated with ACE2-AngII signaling. An overview of the
diagnosis and an update on current therapeutic regimens and vaccinations is also provided. |
| Keyword | Cytokine Storm Covid-19 Sars-cov-2 Immune Response Cytokines Diagnosis Therapy Vaccination |
| DOI | 10.7150/ijbs.59272 |
| URL | View the original |
| Indexed By | SSCI |
| WOS ID | WOS:000743978000001 |
| Scopus ID | 2-s2.0-85123342163 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Faculty of Health Sciences |
| Corresponding Author | Zheng WH(鄭文華) |
| Affiliation | 1.Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China. 2.Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. 3.School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. |
| First Author Affilication | Faculty of Health Sciences |
| Corresponding Author Affilication | Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | Yizhou Jiang,Limor Rubin, MD,Tangming Peng,et al. Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy[J]. International Journal of Biological Sciences, 2022, 2022(18), 459-472. |
| APA | Yizhou Jiang., Limor Rubin, MD., Tangming Peng., Linlin Liu., Xingan Xing., Philip Lazarovici., & Zheng WH (2022). Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy. International Journal of Biological Sciences, 2022(18), 459-472. |
| MLA | Yizhou Jiang,et al."Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy".International Journal of Biological Sciences 2022.18(2022):459-472. |
| Files in This Item: | Download All | |||||
| File Name/Size | Publications | Version | Access | License | ||
| ijbsv18p0459.pdf（877KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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