The global optimization of sensor locations and a sensitivity analysis based on the minimization of interferences due to wireless communications between sensors are studied in the presence of additive white Gaussian noise (AWGN). We used a Gram matrix approach for robust determination of sensor locations by minimizing the interferences (maximizing the signal strength) among sensors for engine health monitoring systems. In order to solve the problem of optimum placement, an iterative algorithm for maximizing the determinant of the Gram matrix is proposed and implemented. The sensitivity criterion proposed in this paper is the spectral number of the Frobenius norm of the Gram matrix associated with sensor readings. We derived the necessary conditions under which the number of sensors and the optimal sensor locations will remain unchanged when the data measured for sensitivity analysis is affected by AWGN. Our theoretical results are verified by simulations providing details concerning numerical implementations.