IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprussideinsult

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	IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprussideinsult
	Haitao Wang 1; Sufen Liao 1; Ruojun Geng 1; Yongxin Zheng &1; Rifang Liao 1; Fengxia Yan 1; Thilini Thrimawithana 1; Peter J. Little 4; Zhong-Ping Feng 3; Philip Lazarovic 2; Wenhua Zheng1
	2015-04-01
Source Publication	J Mol Neurosci
ISSN	0895-8696
Pages	931-940
Abstract	The pathological increase in the levels of the second messenger nitric oxide (NO) in the vitreous cavity and retina leads to injury and cell death of the retinal pigment epithelium (RPE) cells and eventually may contribute to the occurrence and development of diabetic retinopathy. In this study, we developed a cellular model of retinopathy using D407 cells (a human RPE cell line) exposed to sodium nitroprusside (SNP) and investigated the protective effect of the insulin-like growth factor-1 (IGF-1) towards this insult. Cell death and apoptosis were examined by the methyl thiazolyl tetrazolium assay and Hoechst staining, respectively
Keyword	Insulin-like Growth Factor-1 . Retinal Pigment Epithelium . Nitric Oxide . Apoptosis . Akt . Map Kinase . Protection
Language	英語English
The Source to Article	PB_Publication
Document Type	Journal article
Collection	DEPARTMENT OF PHARMACEUTICAL SCIENCES
Corresponding Author	Wenhua Zheng
Affiliation	1.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China 2.Discipline of Pharmacy, School of Medical Sciences and Diabetes Complications Group, Health Innovations Research Institute, RMIT University, Bundoora, Melbourne, VIC 3083, Australia 3.Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, ON, Canada M5S 1A8 4.School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
Recommended Citation GB/T 7714	Haitao Wang,Sufen Liao,Ruojun Geng,et al. IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprussideinsult[J]. J Mol Neurosci, 2015, 931-940.
APA	Haitao Wang., Sufen Liao., Ruojun Geng., Yongxin Zheng &., Rifang Liao., Fengxia Yan., Thilini Thrimawithana., Peter J. Little., Zhong-Ping Feng., Philip Lazarovic., & Wenhua Zheng (2015). IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprussideinsult. J Mol Neurosci, 931-940.
MLA	Haitao Wang,et al."IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprussideinsult".J Mol Neurosci (2015):931-940.

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