| Status | 已發表Published |
| Chemically Bondingof Amantadine with Gardenamide A Enhances the Neuroprotective Effects againstCorticosterone-Induced Insults in PC12 Cells. | |
Zheng, W.
| |
| 2015-09-21 | |
| Source Publication | Int J Mol Sci
 |
| ISSN | 1422-0067 |
| Pages | 22795-22810 |
| Abstract | Two amantadine (ATD)-gardenamide A (GA) ligands have been designed and synthesized. The bonding of ATD with GA through a methylene carbonyl brigde (L1) enhances the neuroprotective effect against corticosterone (CORT)-induced impairments in PC12 cells; while the bonding through a succinyl brigde (L2) does not. L1 reduces the level of reactive oxygen species (ROS) and cell apoptosis generated by CORT. It restores CORT-changed cell morphology to a state that is closed to normal PC12 cells. One mechanism of L1 to attenuate CORT-induced cell apoptosis is through the adjustment of both caspase-3 and Bcl-2 proteins. Like GA, both nNOS and eNOS might be involved in the neuroprotective mechanism of L1. All the evidences suggest that L1 may be a potential agent to treat depression. |
| Keyword | NMDA amantadine eNOS gardenamide A nNOS neuroprotection |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 16669 |
| Document Type | Journal article |
| Collection | University of Macau |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Zheng, W.. Chemically Bondingof Amantadine with Gardenamide A Enhances the Neuroprotective Effects againstCorticosterone-Induced Insults in PC12 Cells.[J]. Int J Mol Sci, 2015, 22795-22810. |
| APA | Zheng, W..(2015). Chemically Bondingof Amantadine with Gardenamide A Enhances the Neuroprotective Effects againstCorticosterone-Induced Insults in PC12 Cells.. Int J Mol Sci, 22795-22810. |
| MLA | Zheng, W.."Chemically Bondingof Amantadine with Gardenamide A Enhances the Neuroprotective Effects againstCorticosterone-Induced Insults in PC12 Cells.".Int J Mol Sci (2015):22795-22810. |
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