Forkhead box protein O , a family of transcription factors integrating diverse biological functions

Status	已發表Published
	Forkhead box protein O , a family of transcription factors integrating diverse biological functions
	Zheng, W.
Subtype	著Authored
	2018
Publisher	Sangdun Choi- SpringerReference
Abstract	Forkhead box (Fox) proteins are a family of transcription factors that regulate the transcription of genes regulating diverse cellular processes, including cell survival, apoptosis, oxidative stress response and redox signaling, proliferation, differentiation metabolism and life span. Fox proteins are classified into subclasses FoxA - FoxS and sub-group O (FoxO) proteins are a subgroup of the Fox family, which is characterized by a conserved DNA-binding domain (the ‘Forkhead box’, or Fox). This domain could recognize the specific DNA sequence localized in the promoter and thus regulate the transcription/expression of these genes. Forkhead gene (fkh) was cloned for the first time from the fly Drosophila melanogaster and has been identified to play important roles during the formation of the anterior and posterior gut of the embryo. Genetic mutation in fkh gene induced defects in head fold involution during the process of embryogenesis, resulting in a characteristic spiked head appearance in adult flies (Weigel et al., 1989). Weigle and Jäckle compared the sequence of Fkh protein and HNF-3A protein and proposed the existence of a new class of transcription factors that is conserved from Drosophila to mammals (Lai et al., 1990, Weigel and Jackle, 1990), and coined the name “forkhead
Keyword	Forkhead box protein O FoxO1 FoxO1a FKH1 FKHR FoxO3 FoxO3a FKHRL1 AF6q21 DAF-16 dFoxO FKHRL1P2 FoxO4 AFX FoxO6.
ISBN	9783319671987
Language	英語English
The Source to Article	PB_Publication
PUB ID	23370
Document Type	Book
Collection	University of Macau
Corresponding Author	Zheng, W.
Recommended Citation GB/T 7714	Zheng, W.. Forkhead box protein O , a family of transcription factors integrating diverse biological functions[M]:Sangdun Choi- SpringerReference, 2018.
APA	Zheng, W..(2018). Forkhead box protein O , a family of transcription factors integrating diverse biological functions. Sangdun Choi- SpringerReference.

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