Interactome analysis of ERα and AP-2γ in breast cancer cells by Rapid Immunoprecipitation and Mass spectrometry of Endogenous proteins (RIME)

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	Interactome analysis of ERα and AP-2γ in breast cancer cells by Rapid Immunoprecipitation and Mass spectrometry of Endogenous proteins (RIME)
	Cui, G; Chang, S; Barun, P; Jadhao, S; Lam, M; Lei, K; Poon, T; Cheung, E
	2018-06-01
Source Publication	5th Macau Symposium on Biomedical Sciences
Abstract	Breast cancer is a widely distributed cancer type in women worldwide. About 70% of breast tumors are estrogen receptor a (ERa) positive, and progression of the tumour is believed to be regulated by the activity of this hormone-mediated transcription factor. Today’s treatment strategy for ER positive tumours involve direct blockage of receptor activation or by preventing estrogen synthesis. However, these modalities of treatment still causes number of patients to develop a recurrence, suggesting that it is vital to increase our knowledge about ERa transcription. AP-2γ (TFAP2C) is highly expressed, and is a collaborating factor in ERa-dependent transcription in breast cancer cells. However, the physical and functional interactions between AP-2γ and ERa has not been studied yet. In this study, we apply recent proteomics tools called RIME (Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins), to discover novel interacting factors of AP-2γ and/or ERa, revealing transcriptional networks and will perform cellular, molecular, and genomics studies to explore the importance of novel factors in ERa-dependent transcription in breast cancer cells.
Keyword	estrogen receptor AP-2gamma breast cancer
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	40993
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Cheung, E
Recommended Citation GB/T 7714	Cui, G,Chang, S,Barun, P,et al. Interactome analysis of ERα and AP-2γ in breast cancer cells by Rapid Immunoprecipitation and Mass spectrometry of Endogenous proteins (RIME)[C], 2018.
APA	Cui, G., Chang, S., Barun, P., Jadhao, S., Lam, M., Lei, K., Poon, T., & Cheung, E (2018). Interactome analysis of ERα and AP-2γ in breast cancer cells by Rapid Immunoprecipitation and Mass spectrometry of Endogenous proteins (RIME). 5th Macau Symposium on Biomedical Sciences.

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