Residential College | false |
Status | 已發表Published |
Multi-Label Learning With Fuzzy Hypergraph Regularization for Protein Subcellular Location Prediction | |
Jing Chen1,2; Yuan Yan Tang1,2; C. L. Philip Chen1; Bin Fang3; Yuewei Lin2; Zhaowei Shang3 | |
2014-12-01 | |
Source Publication | IEEE Transactions on Nanobioscience |
ISSN | 1536-1241 |
Volume | 13Issue:4Pages:438-447 |
Abstract | Protein subcellular location prediction aims to predict the location where a protein resides within a cell using computational methods. Considering the main limitations of the existing methods, we propose a hierarchical multi-label learning model FHML for both single-location proteins and multi-location proteins. The latent concepts are extracted through feature space decomposition and label space decomposition under the nonnegative data factorization framework. The extracted latent concepts are used as the codebook to indirectly connect the protein features to their annotations. We construct dual fuzzy hypergraphs to capture the intrinsic high-order relations embedded in not only feature space, but also label space. Finally, the subcellular location annotation information is propagated from the labeled proteins to the unlabeled proteins by performing dual fuzzy hypergraph Laplacian regularization. The experimental results on the six protein benchmark datasets demonstrate the superiority of our proposed method by comparing it with the state-of-the-art methods, and illustrate the benefit of exploiting both feature correlations and label correlations. |
Keyword | Dictionary Learning Hypergraph Regularization Multi-label Learning Protein Subcellular Localization |
DOI | 10.1109/TNB.2014.2341111 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Biochemistry & Molecular Biology ; Science & Technology - Other Topics |
WOS Subject | Biochemical Research Methods ; Nanoscience & Nanotechnology |
WOS ID | WOS:000345906200010 |
Publisher | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA |
Scopus ID | 2-s2.0-84914693219 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | University of Macau |
Corresponding Author | Jing Chen; Yuan Yan Tang; C. L. Philip Chen; Bin Fang; Yuewei Lin; Zhaowei Shang |
Affiliation | 1.Faculty of Science and Technology, University of Macau, Taipa, Macau 2.Chongqing University, Chongqing 400030, China 3.college of Computer Science, Chongqing University, Chongqing 400030, China 4.University of South Carolina, Columbia, SC 29208 USA |
First Author Affilication | Faculty of Science and Technology |
Corresponding Author Affilication | Faculty of Science and Technology |
Recommended Citation GB/T 7714 | Jing Chen,Yuan Yan Tang,C. L. Philip Chen,et al. Multi-Label Learning With Fuzzy Hypergraph Regularization for Protein Subcellular Location Prediction[J]. IEEE Transactions on Nanobioscience, 2014, 13(4), 438-447. |
APA | Jing Chen., Yuan Yan Tang., C. L. Philip Chen., Bin Fang., Yuewei Lin., & Zhaowei Shang (2014). Multi-Label Learning With Fuzzy Hypergraph Regularization for Protein Subcellular Location Prediction. IEEE Transactions on Nanobioscience, 13(4), 438-447. |
MLA | Jing Chen,et al."Multi-Label Learning With Fuzzy Hypergraph Regularization for Protein Subcellular Location Prediction".IEEE Transactions on Nanobioscience 13.4(2014):438-447. |
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