Autoantigens Signal Through Chemokine Receptors: Uveitis Antigens Induce CXCR3 and CXCR5 Expressing Lymphocytes and Immature Dendritic Cells to Migrate.

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Autoantigens Signal Through Chemokine Receptors: Uveitis Antigens Induce CXCR3 and CXCR5 Expressing Lymphocytes and Immature Dendritic Cells to Migrate.
	Howard, O.; Dong, H.; Su, Sh.; Caspi, R.; Chen, X.; Plotz, P.; Oppenheim, J.
	2005-06-01
Source Publication	Blood
ISSN	0006-4971
Pages	4207-4214
Abstract	We tested the hypothesis that interaction between autoantigens and chemoattractant receptors may be an important step in the development of autoimmunity. The retinal autoantigens S-antigen (S-Ag) and interphotoreceptor retinoid binding protein (IRBP) can induce autoimmune uveitis in rodent models. We evaluated the chemotactic activity of S-Ag and IRBP and found that both induced migration of human and mouse immature dendritic cells (iDCs) and lymphocytes, but not neutrophils, monocytes, or mature DCs. Cross-desensitization studies and single-receptor transfected cells revealed that subfamily of alpha chemokine receptors CXCR5 and CXCR3 mediated the chemotactic effect of IRBP, while only CXCR3 was required for the chemotactic response to S-Ag. Examination of the relationships between chemoattraction and the ability to elicit pathology at the protein or peptide levels in the mouse uveitis model revealed dissociation of the capacity to induce uveitis, lymphocyte proliferation, and chemoattraction. These studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5.
Keyword	EXPERIMENTAL AUTOIMMUNE UVEITIS HEMATOPOIETIC PROGENITOR CELLS T LYMPHOCYTES
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	34806
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Howard, O.
Recommended Citation GB/T 7714	Howard, O.,Dong, H.,Su, Sh.,et al. Autoantigens Signal Through Chemokine Receptors: Uveitis Antigens Induce CXCR3 and CXCR5 Expressing Lymphocytes and Immature Dendritic Cells to Migrate.[J]. Blood, 2005, 4207-4214.
APA	Howard, O.., Dong, H.., Su, Sh.., Caspi, R.., Chen, X.., Plotz, P.., & Oppenheim, J. (2005). Autoantigens Signal Through Chemokine Receptors: Uveitis Antigens Induce CXCR3 and CXCR5 Expressing Lymphocytes and Immature Dendritic Cells to Migrate.. Blood, 4207-4214.
MLA	Howard, O.,et al."Autoantigens Signal Through Chemokine Receptors: Uveitis Antigens Induce CXCR3 and CXCR5 Expressing Lymphocytes and Immature Dendritic Cells to Migrate.".Blood (2005):4207-4214.

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