BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57bl/6 mice

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57bl/6 mice
	Chen, X.; Oppenheim, J.; Howard, O.
	2005-07-01
Source Publication	Journal of Leukocyte Biology
ISSN	0741-5400
Pages	114-121
Abstract	Increasing evidence indicates that CD4(+)CD25(+) T regulatory (Treg) cells control a wide spectrum of immune responses. The initial identification of CD4(+)CD25(+) Treg cell as a "professional suppressor" was based on observations made in BALB/c mice. This mouse strain is well known to preferentially develop T helper cell type 2 responses, to he more susceptible to intracellular parasite infection, to have a higher tumor incidence, and to be more resistant to the induction of autoimmune diseases, as compared with C57BL/6 (116) mice. We therefore decided to compare Treg cell function of B6 and BALB/c mice. We observed that the frequency of CD4(+)CD25(+) T cells in the thymus and peripheral lymphoid organs of BALB/c mice was higher than in B6 mice. CD4(+)CD25(+) Treg cells from both mouse strains shared similar phenotypic properties, including expression of characteristic immunological markers and hyporesponsiveness to T cell receptor cross-linking and in their capacity to suppress proliferation of BAILB/c CD4(+)CD25(-) T responder (Tres) cells. However, CD4(+)CD25(-) Tres cells from B6 mice were notably less susceptible to suppression by CD4(+)CD25(+) Treg cells from either mouse strain. Our data suggest that the number and the level of suppression of CD4(+)CD25(+) Treg cells for CD4(+)CD25(-) Tres cells may be dictated by genetic background. Our data also suggest that differences in the CD4(+)CD25(+) Treg cell number and the susceptibility of CD4(+)CD25(-) Tres cells may, at least in part, account for the differences in immune response between B6 and BALB/c strains of mice.
Keyword	rodent T lymphocytes tolerance/suppression/anergy
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	34799
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Chen, X.
Recommended Citation GB/T 7714	Chen, X.,Oppenheim, J.,Howard, O.. BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57bl/6 mice[J]. Journal of Leukocyte Biology, 2005, 114-121.
APA	Chen, X.., Oppenheim, J.., & Howard, O. (2005). BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57bl/6 mice. Journal of Leukocyte Biology, 114-121.
MLA	Chen, X.,et al."BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57bl/6 mice".Journal of Leukocyte Biology (2005):114-121.

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