| Status | 已發表Published |
| Dendritic cells as a pharmacological target of Traditional Chinese Medicine | |
Chen, X. ; Yang, L.; Howard, O.; Oppenheim, J.
| |
| 2006-12-01 | |
| Source Publication | Cellular & Molecular Immunology
 |
| ISSN | 1672-7681 |
| Pages | 401-410 |
| Abstract | Dendritic cells (DCs) represent a heterogeneous population of professional antigen-presenting cells (APCs) that play a central role in the initiation and regulation of immune responses. There is considerable evidence that DCs can be used as therapeutic targets for pharmacological modulation of immune responses. Traditional Chinese medicine (TCM) has a long-standing history of using herbal medicine in the treatment of variety of human diseases. Many of the clinical effects of TCM have reportedly been attributed to the up- or down-regulation of immune responses. Accumulating evidence indicates that TCM and its components can interfere with immune responses at the earliest stage by targeting key functions of DCs. Here, we review those published studies of TCM with respect to their effects on immunobiological functions of DCs. Investigations based on both chemical entities derived from TCM as well as TCM herbal mixtures are presented. These studies suggest that various TCM herbal medicines have the capacity to inhibit or promote major functions of DCs, such as differentiation, maturation, cytokine production, survival, antigen uptake and presentation as well as trafficking. These studies have revealed novel biological effects of TCM and documented the utility of this approach to discover novel biological modifier of DC functions derived from natural sources. |
| Keyword | dendritic cell traditional Chinese medicine |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 34791 |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Chen, X. |
| Recommended Citation GB/T 7714 | Chen, X.,Yang, L.,Howard, O.,et al. Dendritic cells as a pharmacological target of Traditional Chinese Medicine[J]. Cellular & Molecular Immunology, 2006, 401-410. |
| APA | Chen, X.., Yang, L.., Howard, O.., & Oppenheim, J. (2006). Dendritic cells as a pharmacological target of Traditional Chinese Medicine. Cellular & Molecular Immunology, 401-410. |
| MLA | Chen, X.,et al."Dendritic cells as a pharmacological target of Traditional Chinese Medicine".Cellular & Molecular Immunology (2006):401-410. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment