Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
	Mazzucchelli, R.; Hixon, J.; Spolski, R.; Chen, X.; Li, W.; Hall, V.; Willette-Brown, J.; Hurwitz, A.; Leonard, W.; Durum, S.
	2008-10-15
Source Publication	Blood
ISSN	0006-4971
Pages	3283-3292
Abstract	Interleukin-7 (IL-7), a cytokine produced by stromal cells, is required for thymic development and peripheral homeostasis of most major subsets of T cells. We examined whether regulatory T (Treg) cells also required the IL-7 pathway by analyzing IL-7Ralpha(-/-) mice. We observed a striking reduction in cells with the Treg surface phenotype (CD4, CD25, GITR (glucocorticoid-induced tumor necrosis factor [TNF]-like receptor), CD45RB, CD62L, CD103) or intracellular markers (cytotoxic T-lymphocyte-associated antigen-4, CTLA-4, and forkhead box transcription factor 3, Foxp3). Foxp3 transcripts were virtually absent in IL-7Ralpha(-/-) lymphoid tissues, and no Treg cell suppressive activity could be detected. There are 2 known ligands for IL-7Ralpha: IL-7 itself and thymic stromal lymphopoietin (TSLP). Surprisingly, mice deficient in IL-7 or the other chain of the TSLP receptor (TSLPR) developed relatively normal numbers of Treg cells. Combined deletion of IL-7 and TSLP receptor greatly reduced Treg cell development in the thymus but was not required for survival of mature peripheral Treg cells. We conclude that Treg cells, like other T cells, require signals from the IL-7 receptor, but unlike other T cells, do not require IL-7 itself because of at least partially overlapping actions of IL-7 and TSLP for development of Treg cells.
Keyword	GROWTH-FACTOR-BETA INTERLEUKIN-7 RECEPTOR AUTOIMMUNE-DISEASE
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	34774
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Durum, S.
Recommended Citation GB/T 7714	Mazzucchelli, R.,Hixon, J.,Spolski, R.,et al. Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.[J]. Blood, 2008, 3283-3292.
APA	Mazzucchelli, R.., Hixon, J.., Spolski, R.., Chen, X.., Li, W.., Hall, V.., Willette-Brown, J.., Hurwitz, A.., Leonard, W.., & Durum, S. (2008). Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.. Blood, 3283-3292.
MLA	Mazzucchelli, R.,et al."Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.".Blood (2008):3283-3292.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh