Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells (review)

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells (review)
	Chen, X.; Oppenheim, J.
	2011-10-01
Source Publication	International Immunopharmacology
ISSN	1567-5769
Pages	1489-1496
Abstract	Authenticating markers for the functional suppressive CD4(+)FoxP3(+) regulatory T cells (Tregs) are important for the quantitative identification and enrichment of viable Tregs for possible therapeutic use. CD25 as a surrogate marker of Tregs has some limitations, which prompted investigators to identify more specific marker(s) of Tregs. The search for a firm molecular definition of Tregs resulted in the identification of FoxP3 as a better marker of this subset of CD4 cells. Nevertheless, FoxP3(+) Tregs are phenotypically and functionally heterogeneous. Even in normal mice, only a minority of FoxP3(+) T cells are potent suppressor cells. Therefore, additional marker(s) are required for delineation of truly functional Tregs. In this review, the studies identifying markers of functional Tregs, both in mouse and in human, and their functional implications are discussed. Our finding that TNFR2, which mediates the effect of TNF on the activation of Tregs, is a superb marker of the most suppressive subset of mouse Tregs and its application in the identification of functional human Tregs will also be reviewed.
Keyword	Regulatory T cells Cellular markers Immunosuppressive function
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	34689
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Chen, X.
Recommended Citation GB/T 7714	Chen, X.,Oppenheim, J.. Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells (review)[J]. International Immunopharmacology, 2011, 1489-1496.
APA	Chen, X.., & Oppenheim, J. (2011). Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells (review). International Immunopharmacology, 1489-1496.
MLA	Chen, X.,et al."Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells (review)".International Immunopharmacology (2011):1489-1496.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh