| Status | 已發表Published |
| Title | Pharmacological Evaluation of Sigesbeckia Herb and Its Bioactive Ingredient Leocarpinolide B on Rheumatoid Arthritis |
| Author | Linghu, K.G. ; Yu, H. 
|
| Date Issued | 2021 |
| Keyword | Sigesbeckia Herb Multi-original Chinese Medicine Rheumatoid Arthritis Leocarpinolide B |
| Abstract | Rheumatoid arthritis (RA) is a common autoimmune disease characterized by immune dysfunction, chronic inflammation, synovial tissue hyperplasia, cartilage/bone damaging and accompanied with progressive loss of joint function, which significantly affects the life quality of the patients and brings huge economic burden as well as the serious social problems. Sigesbeckiae Herba (SH) is a traditional herb medicine with a long history for management of various inflammation-related diseases (especially for rheumatism) in China and some other Asian countries. In China, the officially authorized plant origins for SH include Sigesbeckia pubescens Makino (SP), S. orientalis L. (SO) and S. glabrescens Makino (SG). However, the rationality for using the three Sigesbeckia plants as the same medicinal material in clinic still need to be further investigated and re-evaluated by modern scientific research based on their chemicals and pharmacological properties. In this study, we aim to make a comprehensive evaluation of the three Sigesbeckia plants and the developed bioactive ingredient (Leocarpinolide B) from SH extract on their anti-inflammatory/anti-arthritic activities and underlying biological mechanisms. |
| Language | 英語English |
| PUB ID | 56369 |
| Document Type | Thesis |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Yu, H. |
| Recommended Citation GB/T 7714 | Linghu, K.G.,Yu, H.. Pharmacological Evaluation of Sigesbeckia Herb and Its Bioactive Ingredient Leocarpinolide B on Rheumatoid Arthritis[D], 2021. |
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