A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy
	Peng, J.; Chen, F.; Liu, Y.; Zhang, F.; Cao, L.; You, Q.; Yang, D.; Chang, Z.; Ge, M.; Li, L.; Wang, Z.; Mei, Q.; Shao, D.; Chen, M.; Dong, W.
	2022
Source Publication	Theranostics
ISSN	1838-7640
Pages	1756-1768
Abstract	Designing a transformable nanosystem with improved tumor accumulation and penetration by tuning multiple physicochemical properties remains a challenge. Here, a near-infrared (NIR) light-driven nanosystem with size and charge dual-transformation for deep tumor penetration is developed. Methods: The core-shell nanotransformer is realized by integrating diselenide-bridged mesoporous organosilica nanoparticles as a reactive oxygen species (ROS)-responsive core with an indocyanine green (ICG)-hybrid N-isopropyl acrylamide layer as a thermosensitive shell. After loading doxorubicin (DOX), negatively charged nanomedicine prevents DOX leakage, rendering prolonged blood circulation time and high tumor accumulation. Results: Upon NIR light irradiation, mild photothermal effects facilitate the dissociation of the thermosensitive shell to achieve negative-to-positive charge reversal. Meanwhile, ICG-generated ROS cleave the diselenide bond of the organosilica core, resulting in rapid matrix degradation that produces DOX-containing smaller fragments. Such a light-driven dual-transformable nanomedicine simultaneously promotes deep tumor penetration and implements sufficient chemotherapy, along with evoking robust immunogenic cell death effects in vitro and in vivo. With the combination of a programmed cell death protein-1 (PD-1) checkpoint blockade, the nanotransformer remarkably blocks primary tumor growth and pulmonary metastasis of breast cancer with low systemic toxicity. Conclusions: This study develops a promising strategy to realize high tumor accumulation and deep penetration of light-transformable nanomedicine for efficient and safe chemo-immunotherapy.
Keyword	phototherapy light response tumor penetration mesoporous organosilica nanoparticles immunotherapy
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	63092
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Chen, F.; Shao, D.; Dong, W.
Recommended Citation GB/T 7714	Peng, J.,Chen, F.,Liu, Y.,et al. A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy[J]. Theranostics, 2022, 1756-1768.
APA	Peng, J.., Chen, F.., Liu, Y.., Zhang, F.., Cao, L.., You, Q.., Yang, D.., Chang, Z.., Ge, M.., Li, L.., Wang, Z.., Mei, Q.., Shao, D.., Chen, M.., & Dong, W. (2022). A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy. Theranostics, 1756-1768.
MLA	Peng, J.,et al."A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy".Theranostics (2022):1756-1768.

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