Functional Genomics analysis of non-essential protein kinases.

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	Functional Genomics analysis of non-essential protein kinases.
	Tan, K.; Dong, Z.; Wong, M.L.; Parsania, C.; Rai, N.; Wong, K. H.
	2016-05-24
Source Publication	3rd Macau Symposium on Biomedical Sciences 2016
Abstract	Protein kinases accounts for 1.5-2.5% of the eukaryote genomes and are major regulators of cellular functions through reversible phosphorylation of protein targets. Thirty percent of human kinases are implicated in various diseases; hence, kinases are potential targets for many therapies. Using a Functional Genomics and Bioinformatics approach, we found that more than thirty percent of kinases are differentially expressed upon fungal infection of macrophages. These data implied that kinases played an important role in fungal pathogenesis. Using a collection of deletion mutants for 99 non-essential kinases in the model fungus A. nidulans, we undertake a high-throughput Functional Genomics approach to gain a global understanding of the physiological roles of individual kinases at the genome-wide level. Preliminary results of several kinase mutants already advocated probable pathways these kinases are involved. As kinase functions are highly conserved, our result will help to understand the physiological functions of kinases not only in an important model fungus, but also in other fungal species including fungal pathogens and perhaps even in some higher eukaryotes.
Keyword	Functional Genomics protein kinases.
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	21592
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Wong, K. H.
Recommended Citation GB/T 7714	Tan, K.,Dong, Z.,Wong, M.L.,et al. Functional Genomics analysis of non-essential protein kinases.[C], 2016.
APA	Tan, K.., Dong, Z.., Wong, M.L.., Parsania, C.., Rai, N.., & Wong, K. H. (2016). Functional Genomics analysis of non-essential protein kinases.. 3rd Macau Symposium on Biomedical Sciences 2016.

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