Residential College | false |
Status | 已發表Published |
Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near‐Infrared Photoacoustic Imaging and Photothermal Cancer Therapy | |
Xiaoju Men1; Fei Wang2; Haobin Chen2; Yubin Liu1; Xiaoxiao Men2; Ye Yuan3; Zhe Zhang3; Duyang Gao1; Changfeng Wu2; Zhen Yuan1 | |
2020-04-27 | |
Source Publication | Advanced Functional Materials |
ISSN | 1616-301X |
Volume | 30Issue:24Pages:1909673 |
Abstract | Phototheranostic agents in the second near-infrared (NIR-II) window (1000–1700 nm) are emerging as a promising theranostic platform for precision medicine due to enhanced penetration depth and minimized tissue exposure. The development of metabolizable NIR-II nanoagents for imaging-guided therapy are essential for noninvasive disease diagnosis and precise ablation of tumors. Herein, metabolizable highly absorbing NIR-II conjugated polymer dots (Pdots) are reported for the first time for photoacoustic imaging guided photothermal therapy (PTT). The unique design of low-bandgap D-A π-conjugated polymer (DPP-BTzTD) together with modified nanoreprecipitation conditions allows to fabricate NIR-II absorbing Pdots with ultrasmall (4 nm) particle size. Extensive experimental tests demonstrate that the constructed Pdots exhibit good biocompatibility, excellent photostability, bright photoacoustic signals, and high photothermal conversion efficiency (53%). In addition, upon tail-vein intravenous injection of tumor-bearing mice, Pdots also show high-efficient tumor ablation capability with rapid excretion from the body. In particular, both in vitro and in vivo assays indicate that the Pdots possess remarkable PTT performance under irradiation with a 1064 nm laser with 0.5 W cm−2 , which is much lower than its maximum permissible exposure limit of 1 W cm−2 . This pilot study thus paves a novel avenue for the development of organic semiconducting nanoagents for future clinical translation. |
Keyword | Photoacoustic Imaging Photothermal Therapy Polymer Dots Second Near-infrared Window Semiconducting Polymers |
DOI | 10.1002/adfm.201909673 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
WOS ID | WOS:000528635800001 |
Publisher | WILEY-V C H VERLAG GMBH |
Scopus ID | 2-s2.0-85084122399 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | INSTITUTE OF COLLABORATIVE INNOVATION Faculty of Health Sciences DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION |
Corresponding Author | Zhen Yuan |
Affiliation | 1.Cancer Center,Faculty of Health Sciences,Center for Cognitive and Brain Sciences,University of Macau,999078,Macao 2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China 3.State Key Laboratory on Integrated Optoelectronics,College of Electronic Science and Engineering,Jilin University,Changchun,130012,China |
First Author Affilication | Cancer Centre |
Corresponding Author Affilication | Cancer Centre |
Recommended Citation GB/T 7714 | Xiaoju Men,Fei Wang,Haobin Chen,et al. Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near‐Infrared Photoacoustic Imaging and Photothermal Cancer Therapy[J]. Advanced Functional Materials, 2020, 30(24), 1909673. |
APA | Xiaoju Men., Fei Wang., Haobin Chen., Yubin Liu., Xiaoxiao Men., Ye Yuan., Zhe Zhang., Duyang Gao., Changfeng Wu., & Zhen Yuan (2020). Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near‐Infrared Photoacoustic Imaging and Photothermal Cancer Therapy. Advanced Functional Materials, 30(24), 1909673. |
MLA | Xiaoju Men,et al."Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near‐Infrared Photoacoustic Imaging and Photothermal Cancer Therapy".Advanced Functional Materials 30.24(2020):1909673. |
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