The Aspergillus fumigatus transcription factor RglT is essential for virulence, gliotoxin biosynthesis and self-protection

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	The Aspergillus fumigatus transcription factor RglT is essential for virulence, gliotoxin biosynthesis and self-protection
	Ries, L.; Pardeshi, L.; Dong, Z.; Tan, K.; Steenwyk, J.; Cristina Colabardini, A.; Filho, J.; Preite, N.; Almeida, F.; Jose de Assis, L.; Santos, R.; Bowyer, P.; Bromley, M.; Owens, R.; Doyle, S.; Demasi, M.; Hernández, D.; Netto, L.; Pupo, M.; Rokas, A.; Loures, F.; Wong, K. H.; Goldman, G.
	2020-07-15
Source Publication	PLOS Pathogens
ISSN	1553-7366
Pages	e1008645-e1008645
Abstract	Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune–modulatory determinants, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the correct function and recruitment of neutrophils, an immune cell that produces reactive oxygen species in order to fight A. fumigatus infections. We identified a transcription factor (TF) that is crucial for A. fumigatus oxidative stress resistance, virulence in an immunocompetent murine model of pulmonary aspergillosis, and for modulation of the murine immune responses. This TF regulates biosynthesis and self-protection the expression of gliT and gliF of the GT biosynthetic gene cluster through directly binding to the respective promoter regions in GT-producing conditions. Furthermore, this TF was shown to be crucial for GT biosynthesis and self-protection in A. fumigatus. Homologues of this TF were identified in other fungal classes, with the A. nidulans homologue also regulating the expression of a GT reductase-encoding gene, suggesting conservation of function for this TF in both GT-producing and non-producing species of Aspergillus. In conclusion, this work describes the function of an uncharacterised TF, important for GT biosynthesis and virulence, features that are also important in other fungal species.
Keyword	fungal infection secondary metabolism regulation transcription factor
Language	英語English
The Source to Article	PB_Publication
PUB ID	49806
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Wong, K. H.; Goldman, G.
Recommended Citation GB/T 7714	Ries, L.,Pardeshi, L.,Dong, Z.,et al. The Aspergillus fumigatus transcription factor RglT is essential for virulence, gliotoxin biosynthesis and self-protection[J]. PLOS Pathogens, 2020, e1008645-e1008645.
APA	Ries, L.., Pardeshi, L.., Dong, Z.., Tan, K.., Steenwyk, J.., Cristina Colabardini, A.., Filho, J.., Preite, N.., Almeida, F.., Jose de Assis, L.., Santos, R.., Bowyer, P.., Bromley, M.., Owens, R.., Doyle, S.., Demasi, M.., Hernández, D.., Netto, L.., Pupo, M.., ...& Goldman, G. (2020). The Aspergillus fumigatus transcription factor RglT is essential for virulence, gliotoxin biosynthesis and self-protection. PLOS Pathogens, e1008645-e1008645.
MLA	Ries, L.,et al."The Aspergillus fumigatus transcription factor RglT is essential for virulence, gliotoxin biosynthesis and self-protection".PLOS Pathogens (2020):e1008645-e1008645.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh