| Status | 已發表Published |
| Nanoscale Metal-Organic Particles (NMOPs) with Rapid Clearance for MR Imaging Guided Photothermal Therapy | |
Yang, Y. ; Liu, Z. ; Chen, M. W.
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| 2106-06-20 | |
| Source Publication | Nanoscale Metal-Organic Particles (NMOPs) with Rapid Clearance for MR Imaging Guided Photothermal Therapy
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| Abstract | The Nanoscale metal-organic particles (NMOPs) which are constructed from metal ions and organic bridging ligands via the self-assembly process have recently shown great promises in the area of nanomedicine. Herein, we fabricate NMOPs composed of Mn2+ and a near-infrared (NIR) dye, IR825, obtaining Mn-IR825 NMOPs which are then coated with a shell of poly-dopamine (PDA) and further functionalized with polyethylene glycol (PEG). While Mn2+ in such Mn-IR825@PDA-PEG NMOPs offers strong contrast in T1-weighted magnetic resonance (MR) imaging, IR825 with strong near-infrared (NIR) optical absorbance shows efficient photothermal conversion with great photo-stability in the MONP structure. Upon intravenous injection, Mn-IR825@PDA-PEG shows efficient tumor homing together with rapid renal excretion behaviors, as revealed by MR imaging and confirmed by biodistribution measurement. Notably, when irradiated with an 808-nm laser, tumors on mice with Mn-IR825@PDA-PEG injection are completely eliminated without recurrence within 60 days, demonstrating the high efficacy of photothermal therapy with this agent. This study demonstrates the great potential of MNOPs, or MOF-related nanostructures in general, for applications in nanomedicine and cancer theranostics. Below are several major innovatio |
| Keyword | Nanoscale metal-organic particles nanomedicine Mn-IR825@PDA-PEG |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 23563 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Liu, Z.; Chen, M. W. |
| Recommended Citation GB/T 7714 | Yang, Y.,Liu, Z.,Chen, M. W.. Nanoscale Metal-Organic Particles (NMOPs) with Rapid Clearance for MR Imaging Guided Photothermal Therapy[C], 2106. |
| APA | Yang, Y.., Liu, Z.., & Chen, M. W. (2106). Nanoscale Metal-Organic Particles (NMOPs) with Rapid Clearance for MR Imaging Guided Photothermal Therapy. Nanoscale Metal-Organic Particles (NMOPs) with Rapid Clearance for MR Imaging Guided Photothermal Therapy. |
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