This paper describes a 20 MHz micro-nuclear magnetic resonance (μNMR) transceiver (TRX) featuring a butterflycoil input for chemical/biological assays. It enables integration with a 2D multi-electrode digital microfluidic (DMF) device inside a space-limited portable magnet (0.46 T, 1.25 kg), making multisample management compatible with μNMR measurements, and supporting electronic automation. The transmitter (TX) incorporates a pulse-sequence synthesizer followed by an inverter-based power amplifier (PA), to emit the exciting pulses for magnetizing the protons of the samples. For the receiver (RX), it is headed by a multi-stage low-noise amplifier (LNA) using NMOS-PMOScomplementary differential pairs, achieving a sub-nV/√Hz inputreferred noise at low power. Sixth-order Butterworth low-pass filters constitute the core of the RX I/Q baseband. Their sourcefollower- based topology allows fast and coherent scaling of all poles by the bias current, reducing the dead-time of the RX for better sensitivity. Fabricated in 0.18 μm CMOS, the TRX occupies a die area of 2.1 mm, consumes 6.6/23.7 mW of power in the TX/RX mode, and demonstrates the feasibility of electronic-automated biological (avidin) and chemical (CuSO) assays achieving a detection limit on avidin of 0.2 pmol.