| Status | 已發表Published |
| Interpolated Average CT for Cardiac PET/CT Attenuation Correction – a Simulation Study | |
Mok, S. P. ; Ho, CYT ; Sun, T
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| 2013-05-01 | |
| Source Publication | Supplement to The Journal of Nuclear Medicine
 |
| Pages | 2137-2137 |
| Publication Place | Reston, VA |
| Publisher | The Society of Nuclear Medicine and Molecular Imaging, Inc. |
| Abstract | Objectives: Previously we developed interpolated averaged CT (IACT) as a low dose alternate of cine average CT (CACT) for improved attenuation correction (AC) in thoracic oncology. This study aims to evaluate its effectiveness in reducing respiratory artifacts in cardiac PET/CT. Methods: We used the digital 4D Extended Cardiac Torso phantom (XCAT) with 18F-FDG distribution to simulate respiratory motion of 2, 3 and 4 cm. A longitudinal 2 cm and circumferential 60° lesion with 60% of the normal myocardium uptake was placed at the inferior wall of the myocardium of left ventricle (LV). The respiratory period was binned into 13 phases with average activity and attenuation map to represent static PET and CACT respectively. The attenuation maps of end-inspiration and end-expiration represented 2 helical CTs (HCT-1 and HCT-8). IACT was obtained by averaging the original and interpolated phases generated by B-spline method. Noise-free sinogram with attenuation modeling was generated and reconstructed with different AC maps (CACT, HCTs and IACT) by STIR (Software for Tomographic Image Reconstruction), using OS-EM with up to 300 updates. Bull’s eye plots were generated from the short-axis images and the corresponding circumferential profiles were analyzed for the normal heart. Two regions-of-interest were drawn on lesion and background area to obtain the intensity ratio (IR). Results: The bull’s eye plots of PET-IACT were more similar to PET-CACT from visual assessment. Artifacts were observed especially in PET-HCT-8 in the anterior and inferior wall of LV. The circumferential profiles showed that IACT approached to CACT while HCT-1 showed lower and HCT-8 showed higher intensity as compared to CACT. The IR differences of HCT-8 as compared to the phantom were up to ~15%. Conclusions: Respiratory artifacts in cardiac PET can be reduced with IACT based AC. IACT has the potential to improve cardiac PET/CT imaging. |
| Keyword | PET/CT attenuation correction respiratory artifacts cardiac imaging |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 10672 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING |
| Recommended Citation GB/T 7714 | Mok, S. P.,Ho, CYT,Sun, T. Interpolated Average CT for Cardiac PET/CT Attenuation Correction – a Simulation Study[C], Reston, VA:The Society of Nuclear Medicine and Molecular Imaging, Inc., 2013, 2137-2137. |
| APA | Mok, S. P.., Ho, CYT., & Sun, T (2013). Interpolated Average CT for Cardiac PET/CT Attenuation Correction – a Simulation Study. Supplement to The Journal of Nuclear Medicine, 2137-2137. |
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