Bodipy-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features

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	Bodipy-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features
	Chen, L.; Chen, D.; Jiang, Y.; Zhang, J.; Yu, J.; DuFort, C.; Hingorani, S.; Zhang, X.; Wu, C.; Chiu, D.
	2019-04-12
Source Publication	Angew. Chem. Int. Ed.
ISSN	1433-7851
Pages	7008-7012
Abstract	Bright long-wavelength-excitable semiconducting polymer dots (LWE-Pdots) are highly desirable for in vivo imaging and multiplexed in vitro bioassays. LWE-Pdots have been obtained by incorporating a near-infrared (NIR) emitter into the backbone of a polymer host to develop a binary donor–acceptor (D–A) system. However, they usually suffer from severe concentration quenching and a trade-off between fluorescence quantum yield (f) and absorption cross-section (s). Herein, we describe a ternary component (D1/D2–A) strategy to achieve ultrabright, green laser-excitable Pdots with narrow-band NIR emission by introducing a BODIPY-based assistant polymer donor as D1. The D1/D2–A Pdots possess improved Ff and s compared to corresponding binary D2–A Pdots. Their f is as high as 40.2%, one of the most efficient NIR Pdots reported. The D1/D2–A Pdots show ultrahigh single-particle brightness, 83-fold brighter than Qdot 705 when excited by a 532 nm laser. When injected into mice, higher contrast in vivo tumor imaging was achieved using the ternary Pdots versus the binary D–A Pdots.
Keyword	BODIPY in vivo imaging narrow-band absorption near-infrared emission semiconducting polymer dots
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	44092
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Wu, C.; Chiu, D.
Recommended Citation GB/T 7714	Chen, L.,Chen, D.,Jiang, Y.,et al. Bodipy-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features[J]. Angew. Chem. Int. Ed., 2019, 7008-7012.
APA	Chen, L.., Chen, D.., Jiang, Y.., Zhang, J.., Yu, J.., DuFort, C.., Hingorani, S.., Zhang, X.., Wu, C.., & Chiu, D. (2019). Bodipy-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features. Angew. Chem. Int. Ed., 7008-7012.
MLA	Chen, L.,et al."Bodipy-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features".Angew. Chem. Int. Ed. (2019):7008-7012.

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