Activatable Small-Molecule Photoacoustic Probes that Cross Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	Activatable Small-Molecule Photoacoustic Probes that Cross Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease
	Wang, S.; Sheng, Z.; Yang, Z.; Hu, D.; Long, X.; Feng, G.; Liu, Y.; Yuan, Z.; Zhang, J.; Zheng, H.; Zhang, X.
	2019-07-16
Source Publication	Angew. Chem. Int. Ed.
ISSN	1433-7851
Pages	12415-12419
Abstract	Copper enrichment in the brain is highly related to Alzheimer’s disease (AD) pathogenesis, but in vivo tracing of Cu2+ in the brain by imaging techniques is still a great challenge. In this work, we developed a series of activatable photoacoustic (PA) probes with low molecular weights (< 438 Da), RPS1RPS4, which can specifically chelate with Cu2+ to form radicals with turn-on PA signals in the near-infrared (NIR) region. Introducing the electron-donating group N,N-dimethylaniline into the probe was found to significantly enhance the radical stability and PA intensity. The best probe in the series, RPS1, showed a fast response (within seconds) to Cu2+ with high selectivity and a low PA detection limit of 90.9 nM. Owing to the low molecular weight and amphiphilic structure, RPS1 could effectively cross the blood-brain barrier (BBB) and thus allowed us, for the first time, to visualize Cu2+ in vivo via PA imaging in the brains of AD mice.
Keyword	photoacoustic probe blood-brain barrier Alzheimer’s disease cupric ion
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	44093
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Sheng, Z.; Zhang, X.
Recommended Citation GB/T 7714	Wang, S.,Sheng, Z.,Yang, Z.,et al. Activatable Small-Molecule Photoacoustic Probes that Cross Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease[J]. Angew. Chem. Int. Ed., 2019, 12415-12419.
APA	Wang, S.., Sheng, Z.., Yang, Z.., Hu, D.., Long, X.., Feng, G.., Liu, Y.., Yuan, Z.., Zhang, J.., Zheng, H.., & Zhang, X. (2019). Activatable Small-Molecule Photoacoustic Probes that Cross Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease. Angew. Chem. Int. Ed., 12415-12419.
MLA	Wang, S.,et al."Activatable Small-Molecule Photoacoustic Probes that Cross Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease".Angew. Chem. Int. Ed. (2019):12415-12419.

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