Background/Purpose: Intermittent normobaric hypoxia training, an alternative way to replace of the altitude training for athletes, may be beneficial to treat overweight and obesity. The purpose of this study was to investigate whether physical activity combined with diet control in hypoxia has the additive effect on weight loss compared to normoxia training in young obese adults. Methods: 22 young obese adults (10 males and 12 females, BMI > 28.5kg/m2) were recruited for a 4-week residential camp of weight loss with strict diet control and intensive exercise as well as the unified management of non-physical activities and accommodation in the group of hypoxia training (HT) or normoxia training (NT). Caloric intake was restricted on the energy intake of individual’s desirable weight, and all subjects participated in an exercise intervention of 4 hours a day and 22- hour a week, which included aerobic exercise mainly at 60 -70% maximal heart rate and strength training at 40-50% maximal strength. Compared to exercise at sea level in normoxia training group (NT), subjects in HT experienced 16-hour normoxia training and 6-hour normobaric hypoxia training (HT) each week at moderate simulated altitude (2000 - 3000m). Body composition, blood pressure (BP) and Brachial-ankle pulse wave velocity (PWV) were determined before and after the training camp. Results: After the intervention, significant weight losses were found in these two groups (NT: 4.3 kg, 4.2%, p < 0.1 vs. HT: 6.5kg, 7.0%, p < .01) and weight loss in HT was significant greater than in NT (p < .01). Subjects in HT group had significant improvements in systolic blood pressure, diastolic blood pressure and mean blood pressure were found in HT (SBP: 7.6%, DBP: 6.0%, MBP: 7.1%) when compared to NT group (SBP: 0.2%, DBP: 0.7, MBP: 1.4%). PWV had no training effect in both groups. The change of weight was negatively related to the running distance on treadmill in all subjects (r = -0.48, p < .05). Conclusion: The results shows, combined with diet restriction, 4 weeks of normobaric hypoxia training results in significant improvements in weight loss and blood pressure compared with normoxia training, while there is no extra ameliorative effect caused by hypoxia on arterial stiffness in obese adults. Hypoxia training may improve exercise capacity in young obese adults and thus it could be a considerable method in weight loss to treat obesity.