This paper proposes a quasi-elliptic filter with slot coupling and nonadjacent cross coupling based on the substrate integrated waveguide (SIW) cavity. The slots etched on the top metal plane of SIWcavity are used to produce electrical coupling, and the cross coupling is realized by the microstrip transmission line above the SIW cavity. The coupling strength is mainly controlled by the width and height of the slot. The length of the open-ended microstrip line controls the sign of the cross coupling. The cross coupling with different signs are used in the filter to produce a pair of transmission zeros (TZs) at both sides of the passband. In order to prove the validity, a fourth-order SIW quasi-elliptic filter with TZsat both sides of the passband is fabricated in a two-layer printed circuit board. The measured insertion loss at a center frequency of 3.7 GHz is 1.1 dB. The return loss within the passband is below −18 dB with a fractional bandwidth of 16%. The measured results are in good agreement with the simulated results.