Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities

doi:10.1016/j.phytochem.2022.113280

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	Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities
	Song, Min 1; Chan, Ging1 ; Lin, Li Gen1,2 ; Li, Derong 3; Zhang, Kehan 3; Zhang, Xiao Qi 4; Ye, Wen Cai 4; Li, Na 5; Zhang, Qing Wen1,2
	2022-09-01
Source Publication	Phytochemistry
ISSN	0031-9422
Volume	201 Pages:113280
Abstract	Eleven undescribed tetracyclic triterpenoids, meliazedarachins A–K, along with twenty-six known compounds were isolated from the fruits of Melia azedarach L. Their structures were determined by HRESIMS, UV, IR, NMR, X-ray diffraction, electronic circular dichroism (ECD) spectra, and the modified Mosher's method. The cytotoxic activities of all the isolates were measured. Meliazedarachin K and mesendanin N showed cytotoxicity against five human cancer cell lines with IC values ranging from 9.02 to 31.31 μM. Meliazedarachin K showed significant cytotoxicity against HCT116 cell line with IC value of 9.02 ± 0.84 μM. 21α-methylmelianodiol showed significant cytotoxicity against HCT116 and RKO cell lines with IC values of 10.16 ± 1.22 and 8.57 ± 0.80 μM, respectively.
Keyword	Cytotoxicity MeL.a Azedarach L. Meliaceae Tetracyclic Triterpenoids
DOI	10.1016/j.phytochem.2022.113280
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85132776511
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Faculty of Health Sciences Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) DEPARTMENT OF PHARMACEUTICAL SCIENCES
Corresponding Author	Li, Na; Zhang, Qing Wen
Affiliation	1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, Macao 2.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao, Macao 3.Macau Anglican College, Macao, Macao 4.Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou, 510632, China 5.State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, Macao
First Author Affilication	Institute of Chinese Medical Sciences
Corresponding Author Affilication	University of Macau; Institute of Chinese Medical Sciences; Faculty of Health Sciences
Recommended Citation GB/T 7714	Song, Min,Chan, Ging,Lin, Li Gen,et al. Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities[J]. Phytochemistry, 2022, 201, 113280.
APA	Song, Min., Chan, Ging., Lin, Li Gen., Li, Derong., Zhang, Kehan., Zhang, Xiao Qi., Ye, Wen Cai., Li, Na., & Zhang, Qing Wen (2022). Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities. Phytochemistry, 201, 113280.
MLA	Song, Min,et al."Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities".Phytochemistry 201(2022):113280.

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