| Status | 已發表Published |
| Application of Macrocyclic Molecules and Antidotes and Reversal Agents | |
Wang, R. 
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| 2019-08-23 | |
| Source Publication | 第九届全国大环芳烃超分子化学学术研讨会
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| Abstract | Cucurbit[n]urils (CB[n]), an emerging family of macrocyclic molecules, consist of n glycoluril units connected by 2n methylene groups, and they possess not only a hydrophobic internal cavity that can encapsulate various lipophilic guest molecules, but also the two carbonyl-fringed portals that are good cation-receptors. Our research group has been actively investigating CB[n]’s complexations with a variety of drug molecules and biomedically important molecules during the past several years [1], from both organic chemistry and pharmaceutical sciences perspectives. For instance, we are the first to investigate CB[n]’s potential as a taste-concealing agent and as a reversal agent for toxic reagents or drugs [2-4]. Very recently, we have incorporated CB[n]s and their derivatives into a variety of functional nanobiomaterials for controlled payload release [5-7]. We are also attempting to extend relevant studies into other macrocyclic molecules such as cyclodextrins, calixarenes and pillararenes to fully leverage the unique physical/chemical properties from each family of these host molecules in the construction of nanobiomaterials. In this mini-symposium, we will discuss about these and potentially other applications of CB[n]s in biomedical sciences, particularly the use of these macrocycles and antidotes and reversal agents. |
| Keyword | Cucurbit[n]urils Antidotes |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 52467 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Wang, R.. Application of Macrocyclic Molecules and Antidotes and Reversal Agents[C], 2019. |
| APA | Wang, R..(2019). Application of Macrocyclic Molecules and Antidotes and Reversal Agents. 第九届全国大环芳烃超分子化学学术研讨会. |
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