| Status | 已發表Published |
| Cucurbit[n]uril (n = 7 or 8) as Potential Antidote | |
Wang, R. 
| |
| 2017-10-25 | |
| Source Publication | Proceedings for 2017 Workshop for Chinese Supramolecular Chemists
 |
| Abstract | Cucurbit[7]uril (CB[7]) and cucurbit[8]uril (CB[8]) are two key members of the cucurbit[n]uril (CB[n]) family of macrocycles. Because of the good water solubility of CB[7] and the unique ternary binding properties of CB[8], these two macrocycles have attracted increasing attentions in recent years. In particular, many promising reports (including ours) of exciting applications regarding CB[7] and CB[8] have emerged in the pharmaceutical sciences and complexations of biomolecules, which has become one of the most important areas of potential applications of CB[n]s.[1][2] For instance, we have demonstrated that the stabilities of AGE-breaker drug alagebrium[3] and Vitamin B1 and derivatives[4] were improved significantly upon encapsulation by CB[7]. The bitter taste of the Guinness World’s most bitter substance, denatonium benzoate,[5] was dramatically concealed in vivo upon its encapsulations by CB[7]. Additionally, CB[8] was also employed to be a supramolecular crosslinker to reversibly modulate an antibiotic activity for construction of an eco-friendly antibiotic.[6] Most recently, we investigated the use of CB[7] in a preclinical mammal model as an oral antidote to decrease the absorption of paraquat (PQ) and detoxify its poisoning effects by forming complexes in the gastrointestinal track. Furthermore, in order to reduce PQ’s toxicity to users while maintaining its weed-control effect, photo-responsive PQ-loaded nanovesicles (here referred to as “a user-friendly herbicide”) were prepared via our novel one-pot approach driven by self-assembly of an amphiphilic host-gest complexes formed between hydrophilic PQ-CB[8] and a hydrophobic azobenzene derivative. In this presentation, we will discuss about our most recent research progress of these efforts. |
| Keyword | Cucurbit[n]uril Antidote |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 38617 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Wang, R.. Cucurbit[n]uril (n = 7 or 8) as Potential Antidote[C], 2017. |
| APA | Wang, R..(2017). Cucurbit[n]uril (n = 7 or 8) as Potential Antidote. Proceedings for 2017 Workshop for Chinese Supramolecular Chemists. |
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